| 银杏叶提取物对急性脑缺血的保护作用 |
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| 引用本文： | 崔艳英,孔祥军,王淑仙. 银杏叶提取物对急性脑缺血的保护作用[J]. 中草药, 1996, 27(1): 22-24 |
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| 作者姓名： | 崔艳英 孔祥军 王淑仙 |
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| 作者单位： | 中国医药研究开发中心!北京，102206 |
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| 摘 要： | 银杏叶提取物（GBE）连续给大鼠灌胃8d，用阻断大鼠双侧椎动脉和颈总动脉方法制备脑缺血病理模型，缺血5min及再灌流1h，记录皮层脑电图（EEG）变化。结果表明：0．2g／kgGBE可促进缺血EEG较快恢复，10min恢复为正常的93％，而对照组仅为46．4％。用结扎小鼠颈总动脉法观察4g／kgGBE可使小鼠存活时间明显延长，说明GBE对急性实验性脑缺血引起的EEG改变和缺血缺氧有明显保护作用。
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| 关 键 词： | 银杏叶提取物 脑缺血 脑电图 存活时间 |
| 收稿时间： | 1994-12-12 |
Protective Effects of Ginkgo (Ginkgo biloba) Extracts on Acute Ischemia in Brains |
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| Cui Yanying,Kong Xiangjun and Wang Shuxian. Protective Effects of Ginkgo (Ginkgo biloba) Extracts on Acute Ischemia in Brains[J]. Chinese Traditional and Herbal Drugs, 1996, 27(1): 22-24 |
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| Authors: | Cui Yanying Kong Xiangjun Wang Shuxian |
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| Affiliation: | National Institute of Pharmaceutical Research and Development, Beijing;National Institute of Pharmaceutical Research and Development, Beijing;National Institute of Pharmaceutical Research and Development, Beijing |
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| Abstract: | Protective effects of Ginkgo biloba extract (GBE) on ischemia in rat and mice brain were studided. The ischemia model in brains was prepared by occlusion of bilateral carotid arteries and vertebra arteries in rat. The results demonstrated that GBE had no effect on electroencephalogram (EEG) of 5 min of ischemia, but it promoted the recovery of EEG during reperfusion. When it was reperfushed for 10 min,amplitude of EEG in the control group only recovered from 17. 2% after ischemia to 46. 6% of normal level. While 0. 2g/kg GBE has a recovery of 93% from normal level. At 4. 0g/kg GBE the life-span of mice with bilateral ligated carotid arteries was significantly lengthened. The above results proved that GBE has some protective effect on anoxia caused by acute ischemia in rat and mouse brain. |
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