| 青黛颗粒对溃疡性结肠炎实验大鼠血清白细胞介素6和10水平的影响 |
| |
| 引用本文： | 李鲜明,宗士群,杜立阳,刘悦,刘艳,李桐,李晓晨,刘清芳,程晓磊,仇靖,陈铭诗.青黛颗粒对溃疡性结肠炎实验大鼠血清白细胞介素6和10水平的影响[J].中国中西医结合消化杂志,2011,19(2):81-83,87. |
| |
| 作者姓名： | 李鲜明 宗士群 杜立阳 刘悦 刘艳 李桐 李晓晨 刘清芳 程晓磊 仇靖 陈铭诗 |
| |
| 作者单位： | 中国医科大学附属第一医院中医科,辽宁沈阳,110001 |
| |
| 基金项目： | 辽宁省自然科学基金资助项目 |
| |
| 摘 要： | 目的]观察青黛颗粒对溃疡性结肠炎（UC）实验大鼠血清白细胞介素6（IL-6）和白细胞介素10（IL-10）水平的影响,探讨其治疗UC可能的作用机制。方法]将52只SD大鼠采用三硝基苯磺酸（TNBS）法制备UC大鼠模型。造模结束后第2天取4只大鼠处死确定造模成功,余48只随机均分为6组：正常组,模型组,柳氮磺胺嘧啶（SASP）阳性药物治疗（SASP）组,青黛颗粒低、中、高剂量组,各8只。造模后第3天开始各组动物灌胃给药,连续给药10 d,实验第14天通过腹主动脉采血取血清,用ELISA法测定血清IL-6、IL-10水平。结果]青黛颗粒低、中、高3个剂量组与模型组比较,血清IL-6水平显著降低,IL-10水平升高（P〈0.01）;青黛颗粒高剂量组血清IL-6I、L-10水平变化与SASP组比较,差异无统计学意义（P〉0.05）。结论]青黛颗粒治疗实验性UC的作用机制可能与降低IL-6水平,升高IL-10水平有关。
|
| 关 键 词： | 结肠炎 溃疡性 青黛颗粒 白细胞介素6 白细胞介素10 |
Effect of Qingdai granules on the levels of IL-6 and IL-10 in the serum of rats with ulcerative colitis |
| |
| LI Xian-ming,ZONG Shi-qun,DU Li-yang,LIU Yue,LIU Yan,LI Tong,LI Xiao-chen,LIU Qing-fang,CHENG Xiao-lei,CHOU Jing,CHEN Ming-shi.Effect of Qingdai granules on the levels of IL-6 and IL-10 in the serum of rats with ulcerative colitis[J].Chinese Journal of Integrated Traditional and Western Medicine on Digestion,2011,19(2):81-83,87. |
| |
| Authors: | LI Xian-ming ZONG Shi-qun DU Li-yang LIU Yue LIU Yan LI Tong LI Xiao-chen LIU Qing-fang CHENG Xiao-lei CHOU Jing CHEN Ming-shi |
| |
| Institution: | LI Xian-ming,ZONG Shi-qun,DU Li-yang,LIU Yue,LIU Yan,LI Tong,LI Xiao-chen,LIU Qing-fang,CHENG Xiao-lei,CHOU Jing,CHEN Ming-shi(Department of TCM,the First Affiliated Hospital of ChinaMedical University,Shenyang 110001,China) |
| |
| Abstract: | Objective]To investigate the effect of Qingdai granules(QDG)on the serum levels of IL-6 and IL-10 in rats with ulcerative colitis.Methods]Ulcerative colitis was induced in rats by giving an enema of trinitrobenzene sulphonic acid(TNBS)and ethanol.The experimental animals were randomly divided into six groups:normal group,model group,sulfasalazine(SASP)group(500 mg/kg),and low-,medium-,and high-dose QDG groups(600,900 and 1,200 mg/kg).Except the normal group,the other groups were given intragastrically nor... |
| |
| Keywords: | ulcerative colitis qingdai granules IL-6 IL-10 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
