| 补肺汤对肺气虚模型大鼠肠神经系统神经递质的影响 |
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| 引用本文： | 杨胜兰,李道本,樊琼,卢芙蓉,陈瑞,薛卡明.补肺汤对肺气虚模型大鼠肠神经系统神经递质的影响[J].中国中西医结合消化杂志,2011,19(2):77-80. |
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| 作者姓名： | 杨胜兰 李道本 樊琼 卢芙蓉 陈瑞 薛卡明 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院中西医结合科,湖北武汉,430022 |
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| 基金项目： | 国家自然科学基金资助项目，湖北省卫生厅科研基金资助课题 |
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| 摘 要： | 目的]观察肺气虚模型大鼠P物质（substance P,SP）、血管活性肠肽（vasoactive intestinal polypeptide,VIP）和一氧化氮（nitric oxide,NO）的改变,探讨其在肠道动力异常病理生理机制中的作用。方法]将60只Wistar大鼠随机分为空白对照组（对照组）、肺气虚模型组（模型组）、补肺汤治疗组（治疗组）,每组20只。模型组造模同时每天给予蒸馏水灌胃,治疗组造模同时给予补肺汤灌胃。造模结束后检测大鼠血浆VIP、血清NO水平,结肠组织SP含量。结果]模型组大鼠VIP、NO水平显著高于对照组,SP含量显著低于对照组,差异有统计学意义（P〈0.01）;经药物干预后,治疗组大鼠VIP、NO水平较模型组显著降低,SP水平较模型组显著升高,差异均有统计学意义（P〈0.05）。结论]肺气虚模型大鼠肠道动力学的异常受肠神经系统分泌的（兴奋性/抑制性）神经递质的介导和调控;补益肺气法通过调控神经递质水平能促进肠道动力恢复。
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| 关 键 词： | 肺气虚 补肺汤 肠道动力 神经递质 |
Effect of Bufei decoction on neurotransmitters in enteric nervous system of rats with Lung-qi deficiency |
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| YANG Sheng-lan,LI Dao-ben,FAN Qiong,LU Fu-rong,CHEN Rui,XUE Ka-ming.Effect of Bufei decoction on neurotransmitters in enteric nervous system of rats with Lung-qi deficiency[J].Chinese Journal of Integrated Traditional and Western Medicine on Digestion,2011,19(2):77-80. |
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| Authors: | YANG Sheng-lan LI Dao-ben FAN Qiong LU Fu-rong CHEN Rui XUE Ka-ming |
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| Institution: | YANG Sheng-lan,LI Dao-ben,FAN Qiong,LU Fu-rong,CHEN Rui,XUE Ka-ming(Department of Integrated Chinese and Western Medicine,Union Hospital,Tongji MedicalCollege,Huazhong University of Science and Technology,Wuhan 430022,China) |
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| Abstract: | Objective]To investigate the alteration of substance P(SP),vasoactive intestinal polypeptide(VIP)and nitric oxide(NO)in rat models with Lung-Qi deficiency and evaluate their roles in the pathophysiology of abnormal intestinal motility.Methods]Thirty Wistar rats were randomized into blank control group(control group),Lung-Qi deficiency model group(model group)and Bufei decoction group(treatment group),20 rats in each group.Rats in the model group and the treatment group were administered intragastrically w... |
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| Keywords: | Lung-Qi deficiency Bufei decoction Intestinal motility Neurotransmitter |
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