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左氧氟沙星联合碳酸氢钠预防伊立替康导致的延迟性腹泻
引用本文:匡薇,肖琦. 左氧氟沙星联合碳酸氢钠预防伊立替康导致的延迟性腹泻[J]. 实用临床医学(江西), 2011, 12(7): 22-24
作者姓名:匡薇  肖琦
作者单位:匡薇,KUANG Wei(泰和县人民医院药剂科,江西,泰和,343700);肖琦,XIAO Qi(南昌大学第一附属医院普外科,南昌,330006)
摘    要:目的 观察左氧氟沙星联合碳酸氢钠预防伊立替康导致的延迟性腹泻的疗效.方法 将30例接受伊立替康方案化疗的晚期癌症患者按随机数字表法分为A,B 2组,每组15例.A组接受伊立替康方案化疗71周,在化疗前1d口服左氧氟沙星0.1g,2次·d(-1),碳酸氢钠片2g,3次·d(-1),连用4 d;B组接受伊立替康方案化疗53周,常规盐酸洛呢丁胺备用,并嘱避免进食奶制品、粗纤维食物、胡椒和咖啡等能导致腹泻食物.对2组总腹泻周数,1-2级、3-4级腹泻发生情况进行比较.结果 A组总腹泻周数为7周((9.8%,7/71),B组总腹泻周数为27周(50.9%,27/53),2组比较差异有统计学意义(P<0.01).A组发生1-2级腹泻周期数为6周(8.5%,6/71),发生3-4级腹泻周期数为1周(1.4%,1/71);B组发生1-2级腹泻周期数为21周(39.6%,21/53),发生3-4级腹泻周期数为6周(11.2%,6/53),2组1-2级、3-4级腹泻周期所占百分率比较差异有统计学意义(P<0.05或P<0.01).结论 左氧氟沙星联合碳酸氢钠能有效预防伊立替康导致的延迟性腹泻.

关 键 词:伊立替康  碳酸氢钠  左氧氟沙星  盐酸洛哌丁胺  延迟性腹泻

Levofloxacin Combined with Sodium Bicarbonate for Prevention of Irinotecan-induced Diarrhea
KUANG Wei,XIAO Qi. Levofloxacin Combined with Sodium Bicarbonate for Prevention of Irinotecan-induced Diarrhea[J]. Practical Clinical Medicine, 2011, 12(7): 22-24
Authors:KUANG Wei  XIAO Qi
Affiliation:KUANG Wei1,XIAO Qi2(1.Pharmacy,Taihe People's Hospital,Taihe 343700,China,2.Department of General Surgery,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China)
Abstract:Objective To observe the therapeutic effects of Levofloxacin combined with sodium bicarbonate in irinotecan-induced diarrhea.Methods A total of 30 patients with advanced colorectal cancer were allocated into group A(n=15) and group B(n=15).Patients in group A were treated with irinotecan chemotherapy for 71 weeks,and were given oral levofloxacin(0.1 g,2 times per day) and sodium bicarbonate tablets(2 g,3 times per day) for 4 days at 1 day before chemotherapy.Patients in group B were treated with irinotecan ...
Keywords:Irinotecan  Sodium bicarbonate  Levofloxacin  Loperamide hydrochloride  delayed diarrhea  
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