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Juvenile nasopharyngeal angiofibroma: no evidence for inheritance or association with familial adenomatous polyposis
Authors:Tuomas Klockars   Suvi Renkonen   Ilmo Leivo   Jaana Hagstr?m  Antti A. M?kitie
Affiliation:(1) Department of Otorhinolaryngology, Head & Neck Surgery, Helsinki University Central Hospital (HUCH), P.O. Box 220, 00029 Helsinki, Finland;(2) Department of Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland
Abstract:Juvenile nasopharyngeal angiofibromas (JNAs) are rare tumors with prominent vascularity and locally destructive growth. The pathogenesis of JNA is largely unknown. A causal association between JNA and familial adenomatous polyposis has been suggested. Twenty-one patients diagnosed with juvenile angiofibroma filled out a detailed patient questionnaire. No patients reported any relatives with nasopharyngeal angiofibroma or familial adenomatous polyposis. No significant regional clustering suggestive for founder effect could be identified. We believe that if there were a strong genetic predisposition or association with familial adenomatous polyposis, it should have been seen in this patient sample.
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