The analgesic and anti-inflammatory effects of 7-oxosandaracopimaric acid isolated from the roots of <Emphasis Type="Italic">Aralia cordata</Emphasis> |
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Authors: | Tae Doo Kim Ji Yun Lee Bong Jae Cho Tae Wook Park Chang Jong Kim |
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Institution: | (1) Skylight Biotech, 100-4 Sunada, Iijima, Akita 010-0911, Japan;(2) Harvestech, 3-1-7 Sannou, Akita 010-0951, Japan;(3) Akita Research Institute for Food and Brewing (ARIF), 4-26 Sanuki, Arayamachi, Akita 010-1623, Japan; |
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Abstract: | The root of Aralia cordata is a traditional medicine for the treatment of inflammation, fever, pain, and spasm in the various diseases in Korea. We
isolated a dibenzylbutyrolactone diterpene acid, 7-oxosandaracopimaric acid (OSA), from the ether fraction of Aralia cordata MeOH extract, and studied the effect of OSA on phenylquinone (PQ)-induced writhing syndrome and PQ-induced capillary permeability
increase, compound 48/80-induced histamine release by peritoneal mast cells, cycloxygenase (COX) activities, and silica-induced
RAW 264.7 cell reactive oxygen species production. OSA (30 mg/kg, p.o.) significantly (p < 0.05) inhibited PQinduced writhes by 25.8% and the PQ-induced capillary permeability increase levels by 33.13% as compared
with PQ control. Furthermore, OSA (10 mM) inhibited COX-1 by 22.82 ± 1.94%, and COX-2 by 15.86 ± 1.35%, respectively, to the
same extent as indomethacin at the same concentration (10 mM). And OSA (3.0 mM) significantly (p < 0.05) inhibited compound 48/80-induced histamine release from rat mast cells, and its activity was similar to that of celebrex
(1 mM), but no piracetam (0.1 mM) inhibited them. OSA did not inhibit ROS production in RAW 264.7 cells. These results indicated
that OSA has analgesic and anti-inflammatory effects due to its inhibitory effects on capillary permeability, COX activities,
and histamine release. |
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