窒息新生儿复苏后凝血功能变化的研究

目的探讨足月新生儿窒息复苏后早期凝血功能的变化及其临床意义。方法检测50例不同窒息程度足月新生儿早期的血小板计数（PLT）、凝血酶原时间、纤维蛋白原及D-二聚体，并与对照组进行比较。结果与对照组比较，足月窒息新生儿早期血小板计数改变不明显（P〉0．05），而凝血酶原时间、D-二聚体及纤维蛋白原与对照组差异有统计学意义（P〈0．01），且窒息程度越严重，纤维蛋白原下降及D-二聚体升高更明显。结论窒息新生儿早期可出现凝血功能的改变，对窒息新生儿进行早期纤维蛋白原及D-二聚体的检测具有重要的临床意义。

Study on the change of the function of hemostasis and coagulation in early stage of asphyxiated newborns

Objective To investigate the early change of the function of hemostasis and coagulation as well as clinical significance in the full-term newborns recoveried from stifle.Methods To detect the platelet count (PLT),prothrombin time,fibrinogen and D-dimer in early stage of 50 newborns with different degrees of asphyxia recovreied from stifle,and compared with the control group.Results Compared with the control group,there were not obvious change in PLT in asphyxiated full-term newborns(P>0.05),and the differences of prothrombin time,D-dimer and fibrinogen were statistically significant(P<0.01),the more serious degree of asphyxia,the lower of the fibrinogen and higer of the D-dimer.Conclusions The function of hemostasis and coagulation can be changed in early stage of newborns recoveried from stifle.The detection of fibrinogen and D-dimer in early stage of newborns recovefied from stifle has important clinica significance.