| 蝙蝠葛苏林碱光学异构体的合成及其钙拮抗活性的研究 |
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| 引用本文： | 孔荣祖 况代武. 蝙蝠葛苏林碱光学异构体的合成及其钙拮抗活性的研究[J]. 中国医药工业杂志, 1991, 22(7): 299-301 |
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| 作者姓名： | 孔荣祖 况代武 |
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| 作者单位： | 中国药科大学 南京210009 |
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| 摘 要： | 以香兰醛和苯乙腈为起始原料,经合成及拆分得到四个光学活性的单苄基异喹啉化合物5～8。进而通过 Ullmann 反应,使5-7,6-8,5-8,6-7结合,然后分别脱苄基得 R,R-、S,S-、R,S-和 S,R-蝙蝠葛苏林碱。药理试验表明,其钙拮抗活性的顺序是 S,R-构型>R,S-构型>R,R-构型>S,S-构型。
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| 关 键 词： | 蝙蝠葛苏林碱 合成 钙通道 |
SYNTHESIS AND CALCIUM ANTAGONIST ACTIVITY OF DAURISOLINE AND ITS OPTICALLY ACTIVE ISOMERS |
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| KONG Rong-Zu KUANG Dai-Wu HUA Wei-Yi. SYNTHESIS AND CALCIUM ANTAGONIST ACTIVITY OF DAURISOLINE AND ITS OPTICALLY ACTIVE ISOMERS[J]. , 1991, 22(7): 299-301 |
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| Authors: | KONG Rong-Zu KUANG Dai-Wu HUA Wei-Yi |
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| Affiliation: | KONG Rong-Zu~* KUANG Dai-Wu HUA Wei-Yi |
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| Abstract: | Daurisoline(1,R,R-configuration)and its optically activeisomers(2,S,S-;3,R,S-;and 4,S,R-)were synthesized from vanillin andbenzyl cyanide as starting materials.Their calcium antagonistic activity sequencewas as follows:4>3>1>2. |
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| Keywords: | daurisoline bisbenzyltetrahydroisoquinoline calcium antagonist synthesis |
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