| 7—氯—6—氟—4—乙氧基喹啉—3—羧酸乙酯的转化 |
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| 引用本文： | 郭惠元,孙兰英.7—氯—6—氟—4—乙氧基喹啉—3—羧酸乙酯的转化[J].中国医药工业杂志,1991,22(8):339-341. |
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| 作者姓名： | 郭惠元 孙兰英 |
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| 作者单位： | 中国医学科学院医药生物技术研究所 北京100050 |
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| 摘 要： | 报道了7-氯-6-氟-4-乙氧基喹啉-3-羧酸乙酯(1)在 DMF 和 DMSO 中的转化反应。在DMSO中加热或用碘化四丁铵催化,转化率100%,转化产物经证明为2和8的混合物。并用~1HNMR 测定了转化产物中2的相对含量。同时考察了3乙基化时不同溶剂对1和2生成比例的影响。
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| 关 键 词： | 喹啉衍生物 氟哌酸 合成 |
CONVERSION ON ETHYL 7-CHLORO-6-FLUORO-4-ETHOXYQUINOLINE-3-CARBOXYLATE |
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| Authors: | GUO Hui-Yuan SUN Lan-Ying CAO Yi-Cheng TIAN Zhi-Ming ZHANG Zhi-Ping |
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| Institution: | GUO Hui-Yuan~* SUN Lan-Ying CAO Yi-Cheng TIAN Zhi-Ming ZHANG Zhi-Ping |
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| Abstract: | Ethyl 7-chloro-6-fluoro-4-ethoxyquinoline-3-carboxylate(1)was con-
verted into 2 and 3 by heating in DMSO with or without Bu_4NI.The ratio of 2 and
3 in the mixture was determined by (?)HNMR.The influence of different solvents and
on the ratio of 1 and 2 was investigated when 3 was subjected to ethylation. |
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| Keywords: | intermediate of norfloxacin quinoline derivatives |
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