| 血管内皮生长因子在视网膜缺血再灌注损伤中的表达 |
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| 引用本文： | 游志鹏,姜德咏,唐朝珍,赵宏伟,刘湘平. 血管内皮生长因子在视网膜缺血再灌注损伤中的表达[J]. 眼外伤职业眼病杂志, 2004, 26(11): 721-723 |
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| 作者姓名： | 游志鹏 姜德咏 唐朝珍 赵宏伟 刘湘平 |
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| 作者单位： | 1. 江西医学院二附院眼科,江西,南昌,330006
2. 中南大学湘雅二医院眼科,湖南,长沙,410011 |
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| 摘 要： | 目的了解VEGFmRNA在大鼠视网膜缺血再灌注损伤中的表达及意义。方法建立大鼠视网膜缺血再灌注模型，以原位杂交法检测VEGFmRNA在大鼠视网膜中的表达，进行统计学处理。结果VEGFmRNA大鼠视网膜缺血再灌注12小时开始表达，第48小时达到最高，以后逐渐减弱。结论VEGFmRNA在大鼠视网膜缺血再注灌注损伤中起重要作用。
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| 关 键 词： | 视网膜／大鼠 缺血再灌注损伤 血管内皮生长因子 |
| 文章编号： | 1004-6461(2004)11-0721-03 |
The research of VEGF expression in rat''''s ischemia-reperfusion injuried retina |
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| YOU Zhi-peng,JIANG De-yong,TANG Chao-zhen,et al.. The research of VEGF expression in rat''''s ischemia-reperfusion injuried retina[J]. Journal of Injuries and Occupational Diseases of the Eye with Ophthalmic Surgeries, 2004, 26(11): 721-723 |
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| Authors: | YOU Zhi-peng JIANG De-yong TANG Chao-zhen et al. |
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| Affiliation: | YOU Zhi-peng,JIANG De-yong,TANG Chao-zhen,et al. Department o f Ophthalmology,The Second Teaching Hospital,Jiangxi Medical College,Nanchang,Ji angxi 330006,China |
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| Abstract: | Objective To study VEGF expression in rat's re tina which injuried by ischemia-reperfusion.Methods The model of rat's retina ischemia-reperfusion was made ,used ISH method to test the VEGFmRNA expression in rat's retina.Results At one hour after ischemia-reperfusion,there was no VEG FmRNA expression in rat's retina,after 12 hours of ischemia-reperfusion,there wa s some VEGFmRNA expressed in retina and reached the hightest level at 48 hours a fter ischemia-reperfusion.Then it began to decrease,but there was VEGFmRNA expre ssion in retina after 72 hours.Conclusion VEGF is very important in rat's retina ischemia-repe rfusion injury. |
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| Keywords: | retina/rat ischemia-reperfusion injury VEGF |
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