氟西汀治疗帕金森病抑郁患者的疗效观察

目的：探讨氟西汀治疗帕金森病（PD）伴抑郁症的临床疗效。方法：选择我院2007年4月～2009年1月收治住院的80例帕金森病患者,将其随机分为治疗组（40例）和对照组（40例）,治疗组给予氟西汀治疗,对照组不使用任何抗抑郁药物。结果：治疗6周后治疗组HAMD评分显著低于对照组（P〈0.01）,使用氟西汀治疗的患者在抑郁疗效方面显著优于对照组（P〈0.01或P〈0.05）。结论：氟西汀治疗帕金森病抑郁疗效显著,患者耐受良好,可明显且快速改善患者抑郁症状。

Clinical observation of Fluoxetine in treatment of Parkinson disease patients with depression

Objective： To explore the clinical curative effect of Fluoxetine on Parkinson disease（PD） patients with depression.Methods： 80 patients with PD were selected from April 2007 to January 2009,which were randomly divided into treatment group（40 cases） and control group（40 cases）,the treatment group was given Fluoxetine,and the control group was given symptomatic treatment without antidepressant.Results： After 6 weeks treatment HAMD scores of treatment group were significantly lower than the control group（P〈0.01）,using Fluoxetine in the treatment of patients with depression had significant efficacy than the control group（P〈0.01 or P〈0.05）.Conclusion： The treatment of PD patients in depression with Fluoxetine has obvious effect,PD patients are well tolerated,may improve depressive symptoms in patients with rapid improvement.