| 浅低温体外循环心脏不停跳瓣膜置换的肺保护 |
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| 引用本文： | 谢晓勇,何巍,冼磊,郑宝石,冯旭,周涛,高建朝. 浅低温体外循环心脏不停跳瓣膜置换的肺保护[J]. 中国组织工程研究与临床康复, 2011, 15(5): 835-838. DOI: 10.3969/j.issn.1673-8225.2011.05.018 |
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| 作者姓名： | 谢晓勇 何巍 冼磊 郑宝石 冯旭 周涛 高建朝 |
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| 作者单位： | 广西医科大学第一附属医院心胸外科,广西壮族自治区南宁市,530021 |
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| 摘 要： | 背景:浅低温体外循环心脏不停跳治疗可能减轻心内直视手术后肺损伤,但进一步的作用机制尚未明确。目的:探讨浅低温体外循环心脏不停跳下二尖瓣置换术肺保护效果。方法:纳入二尖瓣置换患者40例,随机数字表法均分为实验组与对照组,实验组采用浅低温体外循环心脏不停跳治疗,对照组采用中低温心脏停跳体外循环治疗。分别于置换开始和体外循环后30min两个时点收集支气管肺泡灌洗液,检测肿瘤坏死因子α、白细胞介素8、髓过氧化物酶水平;体外循环前及体外循环后30min分别取左右心房血测定中性粒细胞并计算跨肺差值;体外循环前、停机时、停机后1,8h查动脉血气分析,计算呼吸指数。结果与结论:①两组支气管肺泡灌洗液中肿瘤坏死因子α、白细胞介素8、髓过氧化物酶水平及中性粒细胞跨肺差值在体外循环后30min明显升高(P<0.01),但实验组明显低于对照组(P<0.05)。②两组呼吸指数在体外循环停机时、停机后1,8h各时点升高(P<0.05),但实验组升高明显低于对照组(P<0.05)。提示浅低温体外循环心脏不停跳能减轻二尖瓣置后的肺损伤,有较好的肺保护效果。
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| 关 键 词： | 浅低温体外循环心脏不停跳 二尖瓣置换 肺保护 急性肺损伤 体外循环 |
Lung protection of mitral valve replacement operation on beating-heart with mild hypothermic cardiopulmonary bypass |
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| Xie Xiao-yong,He Wei,Xian Lei,Zheng Bao-shi,Feng Xu,Zhou Tao,Gao Jian-chao. Lung protection of mitral valve replacement operation on beating-heart with mild hypothermic cardiopulmonary bypass[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2011, 15(5): 835-838. DOI: 10.3969/j.issn.1673-8225.2011.05.018 |
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| Authors: | Xie Xiao-yong He Wei Xian Lei Zheng Bao-shi Feng Xu Zhou Tao Gao Jian-chao |
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| Affiliation: | Xie Xiao-yong,He Wei,Xian Lei,Zheng Bao-shi,Feng Xu,Zhou Tao,Gao Jian-chao Department of Cardiothoracic Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanjing 530021,Guangxi Province,China |
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| Abstract: | BACKGROUND:The treatment of beating-heart with mild hypothermic cardiopulmonary bypass (CPB) may lessen lung injury after intracardiac operation underdirects vision,but mechanism of action remains unclear. OBJECTIVE:To evaluate the lung protection of mitral valve replacement operation on beating-heart with mild hypothermic CPB. METHODS:A total of 40 patients underwent mitral valve replacements which were randomly divided into experimental group and control group. Patients in the experimental group were perf... |
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