Does H2-receptor antagonist alter the renal function of cyclosporine-treated kidney grafts? |
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Authors: | Sumio Inoue MD Hisayuki Sugimoto Takeshi Nagao Nobuo Akiyama |
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Affiliation: | (1) The Department of Organ Transplantation, Institute of Medical Science, The University of Tokyo, 4-6-1 Shiroganedai, Minato-ku, 108 Tokyo, Japan |
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Abstract: | Histamine-type 2 antagonists (H2-blockers) as represented by cimentidine have been shown to adversely affect renal allograft function, particularly when coadministered
with cyclosporine, currently a major immunosuppressant. To determine whether or not a newer and more powerful H2-blocker, famotidine, would produce similar adverse effects, we assessed seven cyclosporine-treated renal allograft recipients
with regard to changes in their renal function on or off the H2-blocker over a one-week period. Neither the administration nor withdrawal of famotidine (20–40 mg/day) resulted in any significant
changes in serum creatine, BUN, urine output or cyclosporine trough levels, suggesting that famotidine can be safely administered
as an H2-blocker to cyclosporine-treated renal allograft recipients. |
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Keywords: | histamine-type 2 antagonist kidney allograft cyclosporine famotidine |
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