| 中国人精神分裂症患者永生细胞库的建立 |
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| 引用本文： | 曾丽萍,高峰,梅桂森,刘平,高金来,刘福林.中国人精神分裂症患者永生细胞库的建立[J].河北医科大学学报,2001,22(3):143-145,F004. |
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| 作者姓名： | 曾丽萍 高峰 梅桂森 刘平 高金来 刘福林 |
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| 作者单位： | 中国人民解放军第261医院临床实验室 |
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| 摘 要： | 目的 保存精神分裂症特有的基因组资源，方法 采用Epstein Barr(EB)病毒转化技术，把患者外周血B淋巴细胞转化成永生类淋巴母细胞系。结果 建系150个，包括精神分裂症各型、同胞对、双胞胎、核心家庭、三代及三代以旧家系构成永生细胞库。结论 精神分裂症患者基因组保存永生细胞库的建立，为我国精神分裂症分子水平发病机理的研究提供用之不竭的DNA资源。
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| 关 键 词： | 精神分裂症 遗传学 细胞转化 B淋巴细胞 细胞库 |
ESTABLISHMENT OF PERMANENT LYMPHOBLASTOID CELL BANK OF SCHIZOPHRENIC PATIENTS IN CHINA |
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| Zeng Liping,Gao Feng,Mei Guisen,Liu Ping,Gao Jinlai,Lin Fulin.ESTABLISHMENT OF PERMANENT LYMPHOBLASTOID CELL BANK OF SCHIZOPHRENIC PATIENTS IN CHINA[J].Journal of Hebei Medical University,2001,22(3):143-145,F004. |
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| Authors: | Zeng Liping Gao Feng Mei Guisen Liu Ping Gao Jinlai Lin Fulin |
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| Institution: | Beijing 100094 |
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| Abstract: | ObjectiveTo preserve peculiar genomes resources of schizophrenic patients.MethodsThe permanent lymphoblastoid cell lines of schizophrenic patients were established by Epstein Barr virus transformation of peripheral blood B lymphocytes.ResultsThe bank with 150 permanent cell lines from different types,sib-pair,twins and family lines of schizophrenia were established.ConclusionIt is important to establish permanent lymphoblastoid cell bank of schizophenic and provide long-term DNA materials for study of schizophrenic pathogenesis in molecular level in our country. |
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| Keywords: | schizophrenia/genet cell transformation viral B lymphocytes cells pool |
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