| 基质金属蛋白酶9及组织抑制剂因子1与急性呼吸窘迫综合征 |
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| 引用本文： | 江建立,刘先哲. 基质金属蛋白酶9及组织抑制剂因子1与急性呼吸窘迫综合征[J]. 医学综述, 2009, 15(9): 1372-1374 |
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| 作者姓名： | 江建立 刘先哲 |
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| 作者单位： | 1. 三峡医学院科研科,湖北,宜昌,443002
2. 宜昌第一人民医院,湖北,宜昌,443002 |
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| 摘 要： | 基质金属蛋白酶9是降解细胞外基质的重要蛋白酶之一,组织金属蛋白酶抑制剂1是基质金属蛋白酶9的天然抑制剂。二者的比值决定细胞外基质是否处于平衡状态的重要影响因素,故二者在急性呼吸窘迫综合征的发生、发展过程中起着重要作用,是近年急性呼吸窘迫综合征研究的热点之一。
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| 关 键 词： | 基质金属蛋白酶9 组织金属蛋白酶抑制剂1 急性呼吸窘迫综合征 |
Correlations between Metalloprotease-9 and Inhibitor-1 with Acute Respiratory Distress Syndrome |
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| JIANG Jian-li,LIU Xian-zhe. Correlations between Metalloprotease-9 and Inhibitor-1 with Acute Respiratory Distress Syndrome[J]. Medical Recapitulate, 2009, 15(9): 1372-1374 |
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| Authors: | JIANG Jian-li LIU Xian-zhe |
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| Affiliation: | JIANG Jian-li , LIU Xian-zhe. ( l. Department of Scientific Research, Medical College of Three Gorges; 2. First People＇s Hospital of Yichang , Yichang 443002, China) |
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| Abstract: | Metalloprotease-9 （MMP-9） is the major enzymes degradating extracellular matrix. Matrix metalloprotease inhibitor-1 （ TIMP-1 ） is one of its natural inhibitors. The MMP-9/TIMP-1 ratio is one of the major factors, which determine whether the extracellular matrix were in balanced condition. And it has become one of the hotspots in the research of acute respiratory distress syndrome（ ARDS）, and played an important effect in the development of ARDS. |
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| Keywords: | Metalloprotease-9 Tissue inhibitor of metalloproteinase-l Acute respiratory distress syndrome |
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