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Interleukin-6 and selected plasma proteins in healthy persons of different ages |
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| Authors: | Klaus Hager Uwe Machein Stephan Krieger Dieter Platt Gerhard Seefried and Joachim Bauer |
| Institution: | * Clinic for Medical Rehabilitation and Geriatrics, Henriettenfoundation, Schwemannstr. 19, D-30559, Handover, Germany ? Clinic for Psychiatry of the University of Freiburg, Hauptstr. 5, D-79104, Freiburg/Br., Germany ? Chair of Internal Medicine/Gerontology of the University of Erlangen/Nürnberg, Heimerichstr. 58, D-90419, Nürnberg, Germany |
| Abstract: | In the present study, interleukin-6(IL-6) and several acute phase proteins were measured in healthy participants (23–87 years of age). A linear correlation between IL-6 and age was established with an increase of 0.016 pg/ml(00.004) per year of life. Whereas CRP remained below 0.5 mg/dl in all participants, an increase with age for fibrinogen and an inverse relation for albumin as well as transferrin were obtained. However, the increase of IL-6 did not correlate with any of these changes. IL-6 associated diseases may therefore occur more often with advancing age, but in healthy participants IL-6 does not explain the changing plasma protein pattern resembling that of an acute phase reaction. |
| Keywords: | Age Interleukin-6 Acute phase proteins |
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