去甲长春碱或吉西他滨联合顺铂治疗晚期非小细胞肺癌疗效比较

目的: 评价NP(去甲长春碱+顺铂)、GP(吉西他滨+顺铂)两种方案治疗晚期非小细胞肺癌的疗效及毒副反应。方法: 40例晚期非小细胞肺癌随机分为两组,NP组20例,去甲长春碱25mg/m2第1、5天静脉滴注,顺铂80mg/m2第2~4天静脉滴注;GP组20例,吉西他滨800mg/m2第1、5天静脉滴注,顺铂80mg/m2第2~4天静脉滴注;每4周为1周期,连用2周期后评价疗效。结果: NP、GP的有效率分别为35.0%和40%(P>0.05)。NP组白细胞下降静脉炎发生率高于GP组;GP组血小板下降发生率高于NP组(P<0.05和P<0.01)。结论: NP、GP方案治疗晚期非小细胞肺癌的有效率相似,毒性可耐受。

Comparison of the therapeutic effect of 40 advanced non-small cell lung cancers with vinorelbine plus cisplatin and gemcitabine plus cisplatin

Objective:To evaluate the efficacy and toxicity of combination chemotherapy of vinorelbine plus cisplatin and gemcitabine plus cisplatin in the treatment of advanced non-small cell lung cancer(NSCLC).Methods:Forty patients with NSCLC were devided into two groups.Twenty patients received NP(vinorelbine 25 mg/m~2 iv d1.d5 and cisplatin 80 mg/m~2 d2-d4).Twenty patients received GP(gemcitabine 800 mg/m~2 iv d1,d5 and cisplatin 80 mg/m~2 d2-d4).Both groups were recycled every 4 weeks and the therapeutic effect were evaluated after two cycles.Results:The objective response rate was 35% in NP group and 40% in GP group(P>0.05).The leukopenia and the incidence of vein inflammation were higher in the NP group than in the GP group,while thrombocytopenia occurred more frequently in the GP group(P<0.05 and P<0.01).Conclusions:No significiant difference was observed in response rate between two groups.The side effects were tolerated.