Association of obesity risk SNPs in <Emphasis Type="Italic">PCSK1</Emphasis>with insulin sensitivity and proinsulin conversion |
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| Authors: | Martin Heni Axel Haupt Silke A Schäfer Caroline Ketterer Claus Thamer Fausto Machicao Norbert Stefan Harald Staiger Hans-Ulrich Häring Andreas Fritsche |
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| Institution: | 1.Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry,Eberhard Karls University Tübingen, Member of the German Centre for Diabetes Research (DZD),Tübingen,Germany;2.Department of Internal Medicine, Nutritional and Preventive Medicine,Eberhard-Karls-University Tübingen,Tübingen,Germany |
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| Abstract: | Background Prohormone convertase 1 is involved in maturation of peptides. Rare mutations in gene PCSK1, encoding this enzyme, cause childhood obesity and abnormal glucose homeostasis with elevated proinsulin concentrations.
Common single nucleotide polymorphisms (SNPs) within this gene, rs6232 and rs6235, are associated with obesity. We studied
whether these SNPs influence the prediabetic traits insulin resistance, β-cell dysfunction, or glucose intolerance. |
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