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| 心肌缺血再灌注损伤的线粒体通透性转换机制 | |
| 引用本文： | 李敬远,王俊科,曾因明.心肌缺血再灌注损伤的线粒体通透性转换机制[J].国际麻醉学与复苏杂志,2006,27(1):54-57. |
| 作者姓名： | 李敬远 王俊科 曾因明 |
| 作者单位： | 1. 中国医科大学第一医院麻醉科,沈阳,110001;江苏省麻醉医学研究所,江苏省麻醉学重点实验室,徐州,221000 2. 中国医科大学第一医院麻醉科,沈阳,110001 3. 江苏省麻醉医学研究所,江苏省麻醉学重点实验室,徐州,221000 |
| 摘 要： | 线粒体功能障碍存心肌缺血再灌注（ischema／reperfusion I／R）损伤中占有重要地位．近年研究发现线粒体的功能障碍和线粒体通透性转换孔道（mitochondfial permeability transition pore，mPTP）密切相关， |
| 关 键 词： | 心肌缺血再灌注损伤 线粒体通透性 转换机制 线粒体功能障碍 通透性转换孔 研究发现 |
Mitochondrial permeability transition during the myocardium ischemia/reperfusion injury |
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| LI Jing-yuan,WANG Jun-Ke,ZENG Ying-ming.Mitochondrial permeability transition during the myocardium ischemia/reperfusion injury[J].international journal of anesthesiology and resuscitation,2006,27(1):54-57. | |
| Authors: | LI Jing-yuan WANG Jun-Ke ZENG Ying-ming |
| Institution: | Department of Anesthesiology. First Hospital of China Medical University ,Shen yang 110001 China. |
| Abstract: | A central mechanism leading to necrosis and apoptosis during cardiac ischemia/reperfusion is believed to be the mitochondrial permeability transition (MPT), due to opening of mitochondrial permeability transition pore (mPTP), a multiprotein complex formed at the contact site between the inner and outer mitochondrial membranes. MPT is important in the processes of cell damage and death. The regulation of the MPT plays a key role in the regulation of cardiac mitochondria injury, appears of a novel target and high interest in various therapeutic indications for cardioprotective. |
| Keywords: | mitochondrial permeability transition myocardium ischemia/reperfusion injury |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |