MRI纹理分析评价注意缺陷多动障碍

目的 观察MRI纹理分析诊断注意缺陷多动障碍(ADHD)及分型的效果.方法 基于纽约大学医学中心公开MRI数据选取88例ADHD患者(ADHD组)及67名健康受试者(对照组),将ADHD组分为注意力缺陷为主型(ADHD-D亚组(n=32)和混合型(ADHD-C)亚组(n=56),提取并比较受试者脑白质和脑灰质的纹理特征...

MRI texture analysis for observation of attention-deficit hyperactivity disorder

Objective To observe the value of MRI texture analysis in diagnosis and classification of attention deficit hyperactivity disorder (ADHD). Methods Based on the open MRI data of New York University Medical Center, 88 ADHD patients (ADHD group) and 67 healthy subjects (control group) were selected. Patients in ADHD group were divided into predominantly inattentive ADHD (ADHD-I) subgroup (n=32) and combined ADHD (ADHD-C) subgroup (n=56). The texture features of white matter and gray matter were extracted, and the statistical differences among groups/subgroups were calculated. The texture features were compared between ADHD group and control group, as well as ADHD-I subgroup and ADHD-C subgroup. Spearman correlation analysis was used to reduce redundant features with high correlations. The remained features being significantly different between groups/subgroups were used to establish support vector machine (SVM) classification models. The receiver operating characteristic (ROC) curve was drawn, and the area under the curve (AUC) was calculated to evaluate the performance of SVM models for diagnosis and classifying of ADHD. Results There were 12 gray matter features and 14 white matter features being significant different among ADHD-I subgroup, ADHD-C subgroup and control group (all P<0.05). The AUC of SVM model based on 24 gray matter features for differentiating ADHD patients healthy subjects was 0.85, with accuracy of 72.00%, sensitivity of 80.00% and specificity of 60.00%. SVM model combining 1 gray matter and 18 white matter features had an AUC of 0.81, accuracy of 84.00%, sensitivity of 93.33% and specificity of 70.00% for distinguishing different types ADHD. Conclusion MRI texture analysis could be used to diagnose and classify ADHD.