| 白及多糖外用水凝胶的制备与评价 |
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| 引用本文： | 王斯韬,朱峻霄,崔秀明,林亚蒙,杨野,曲媛,王承潇,杨晓艳. 白及多糖外用水凝胶的制备与评价[J]. 中草药, 2017, 48(5): 888-893 |
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| 作者姓名： | 王斯韬 朱峻霄 崔秀明 林亚蒙 杨野 曲媛 王承潇 杨晓艳 |
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| 作者单位： | 昆明理工大学生命科学与技术学院, 云南 昆明 650500;云南省三七资源可持续利用重点实验室, 云南 昆明 650500;国家中医药管理局三七资源可持续发展利用研究室, 云南 昆明 650500;昆明市道地药材可持续发展利用重点实验室, 云南 昆明 650500;昆明理工大学生命科学与技术学院, 云南 昆明 650500;云南省三七资源可持续利用重点实验室, 云南 昆明 650500;国家中医药管理局三七资源可持续发展利用研究室, 云南 昆明 650500;昆明市道地药材可持续发展利用重点实验室, 云南 昆明 650500;昆明理工大学生命科学与技术学院, 云南 昆明 650500;云南省三七资源可持续利用重点实验室, 云南 昆明 650500;国家中医药管理局三七资源可持续发展利用研究室, 云南 昆明 650500;昆明市道地药材可持续发展利用重点实验室, 云南 昆明 650500;云南白药集团中药资源有限公司, 云南 昆明 650502;昆明理工大学生命科学与技术学院, 云南 昆明 650500;云南省三七资源可持续利用重点实验室, 云南 昆明 650500;国家中医药管理局三七资源可持续发展利用研究室, 云南 昆明 650500;昆明市道地药材可持续发展利用重点实验室, 云南 昆明 650500;昆明理工大学生命科学与技术学院, 云南 昆明 650500;云南省三七资源可持续利用重点实验室, 云南 昆明 650500;国家中医药管理局三七资源可持续发展利用研究室, 云南 昆明 650500;昆明市道地药材可持续发展利用重点实验室, 云南 昆明 650500;昆明理工大学生命科学与技术学院, 云南 昆明 650500;云南省三七资源可持续利用重点实验室, 云南 昆明 650500;国家中医药管理局三七资源可持续发展利用研究室, 云南 昆明 650500;昆明市道地药材可持续发展利用重点实验室, 云南 昆明 650500;昆明理工大学生命科学与技术学院, 云南 昆明 650500;云南省三七资源可持续利用重点实验室, 云南 昆明 650500;国家中医药管理局三七资源可持续发展利用研究室, 云南 昆明 650500;昆明市道地药材可持续发展利用重点实验室, 云南 昆明 650500 |
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| 基金项目： | 云南省科技计划项目（2016BAE0024）（21562029） |
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| 摘 要： | 目的以白及多糖为主要基质制备水凝胶并进行质量评价。方法采用水提醇沉法提取白及多糖并用酶解和Sevag法进行纯化。通过傅里叶变换红外光谱、热重分析、热差分析和X射线衍射分析对白及多糖进行表征。将白及多糖作为基质,交联卡波姆940制备得水凝胶。采用旋转流变仪测定水凝胶流变学特性,采用经皮水分散失速率仪测定水凝胶经皮促渗活性,并以止血时间和凝血4项为指标,测定了水凝胶的止血活性。结果白及多糖水凝胶具有较好的黏弹性和物理强度,且具有经皮促渗活性和止血活性。结论白及多糖水凝胶在药物透皮传送系统和伤口敷料应用方面具有巨大潜力。
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| 关 键 词： | 水凝胶 白及多糖 经皮给药系统 皮肤渗透性 止血活性 |
| 收稿时间： | 2016-10-28 |
Preparation and evaluation of novel hydrogel of Bletilla striata polysaccharide |
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| WANG Si-tao,ZHU Jun-xiao,CUI Xiu-ming,LIN Ya-meng,YANG Ye,QU Yuan,WANG Cheng-xiao and YANG Xiao-yan. Preparation and evaluation of novel hydrogel of Bletilla striata polysaccharide[J]. Chinese Traditional and Herbal Drugs, 2017, 48(5): 888-893 |
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| Authors: | WANG Si-tao ZHU Jun-xiao CUI Xiu-ming LIN Ya-meng YANG Ye QU Yuan WANG Cheng-xiao YANG Xiao-yan |
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| Affiliation: | Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;Yunnan Provincial Key Laboratory of Panax notoginseng, Kunming 650500, China;Key Laboratory of Panax notoginseng Resources Sustainable Development and Utilization of State Administration of Traditional Chinese Medicine, Kunming 650500, China;Kunming Key Laboratory of Sustainable Development and Utilization of Famous-Region Drug, Kunming 650500, China;Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;Yunnan Provincial Key Laboratory of Panax notoginseng, Kunming 650500, China;Key Laboratory of Panax notoginseng Resources Sustainable Development and Utilization of State Administration of Traditional Chinese Medicine, Kunming 650500, China;Kunming Key Laboratory of Sustainable Development and Utilization of Famous-Region Drug, Kunming 650500, China;Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;Yunnan Provincial Key Laboratory of Panax notoginseng, Kunming 650500, China;Key Laboratory of Panax notoginseng Resources Sustainable Development and Utilization of State Administration of Traditional Chinese Medicine, Kunming 650500, China;Kunming Key Laboratory of Sustainable Development and Utilization of Famous-Region Drug, Kunming 650500, China;Yunnan Baiyao Group Chinese Medicinal Resources Co., Ltd., Kunming 650502, China;Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;Yunnan Provincial Key Laboratory of Panax notoginseng, Kunming 650500, China;Key Laboratory of Panax notoginseng Resources Sustainable Development and Utilization of State Administration of Traditional Chinese Medicine, Kunming 650500, China;Kunming Key Laboratory of Sustainable Development and Utilization of Famous-Region Drug, Kunming 650500, China;Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;Yunnan Provincial Key Laboratory of Panax notoginseng, Kunming 650500, China;Key Laboratory of Panax notoginseng Resources Sustainable Development and Utilization of State Administration of Traditional Chinese Medicine, Kunming 650500, China;Kunming Key Laboratory of Sustainable Development and Utilization of Famous-Region Drug, Kunming 650500, China;Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;Yunnan Provincial Key Laboratory of Panax notoginseng, Kunming 650500, China;Key Laboratory of Panax notoginseng Resources Sustainable Development and Utilization of State Administration of Traditional Chinese Medicine, Kunming 650500, China;Kunming Key Laboratory of Sustainable Development and Utilization of Famous-Region Drug, Kunming 650500, China;Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;Yunnan Provincial Key Laboratory of Panax notoginseng, Kunming 650500, China;Key Laboratory of Panax notoginseng Resources Sustainable Development and Utilization of State Administration of Traditional Chinese Medicine, Kunming 650500, China;Kunming Key Laboratory of Sustainable Development and Utilization of Famous-Region Drug, Kunming 650500, China |
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| Abstract: | Objective To prepare the hydrogels using Bletilla striata polysaccharides (BSP) as groundmass and evaluate its properties. Methods BSP were successfully extracted and characterized by Fourier Transform Infrared Spectrometer, thermogravimetric analysis, differential thermal analysis, and X-ray diffraction. The BSP was incorporated with Carbopol 940 to prepare hydrogels. Rheological behavior of the gels was investigated by rotational rheometer, skin permeation properties and bioactivities of BSP gels were evaluated by trans-epidermal water loss (TEWL) and blood coagulation examinations respectively using mice as model animals. Results The BSP was pure with complete structure. The BSP gels showed the better viscoelasticity and physical strength from carbopol gel. The gels showed better skin permeation enhancement and hemostatic activity. Conclusion This work demonstrates the skin permeation enhancement and plasma coagulation effects of BSP hydrogels, which show great potential in transdermal drug delivery system and wound dressing. |
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| Keywords: | hydrogels natural polysaccharide transdermal drug delivery system skin permeability hemostatic activity |
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