| 代谢组学在儿科疾病中的应用 |
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| 作者姓名： | 林丽丽 谢彤 汪受传 单进军 |
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| 作者单位： | 1.江苏省儿童呼吸疾病中医药重点实验室，南京中医药大学中医儿科学研究所，江苏 南京?210023 |
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| 摘 要： | 儿童期是人类个体生命周期中的起始阶段，儿科疾病有其特有的生理病理机制及诊疗方法。代谢组学通过监测生物体内源性代谢产物的变化来反应机体的生理或病理状态，并发现疾病相关的生物标记物。近年来，代谢组学技术逐渐被应用于儿科疾病，为疾病的预防、诊断和治疗带来新的契机。文章从“治未病”和“治已病”两个角度出发，综述了代谢组学技术在研究儿科疾病生理病理机制中的应用，并提出其应用于儿科疾病证候学研究的设想。
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| 关 键 词： | 代谢组学 儿科 生理 病理 证候学 |
| 收稿时间： | 2016/12/13 0:00:00 |
| 修稿时间： | 2017/1/5 0:00:00 |
Metabolomics Applied to Pediatric Diseases: Opportunities and Challenges |
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| Authors: | LIN Li-li XIE Tong WANG Shou-chuan SHAN Jin-jun |
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| Institution: | 1.Jiangsu Key Laboratory of Pediatric Respiratory Disease, Institute of Pediatrics, Nanjing University of Chinese Medicine, Nanjing, 210023, China2.Medical Metabolomics Center, Nanjing, 210023, China3.The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China |
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| Abstract: | Childhood is a specific life period. Pediatric disease has its unique physiological and pathological mechanism and thereby it requires distinctive considerations and special treatments. Metabolomics is used to monitor the body's physiological or pathological state by monitoring the changes of endogenous metabolites and biomarkers related to diseases， which provides a new basis for diagnosis and treatment of disease. In recent years， metabolomics has gradually been applied to pediatric diseases， bringing new opportunities for prevention， diagnosis and treatment of the diseases. This paper reviews the application of metabolomics to pathophysiological study of pediatric diseases from the two aspect of "preventive treatment of disease" and "treatment of diseases"， and further put forward the conceive of its application to TCM syndrome research of pediatric diseases. |
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| Keywords: | metabolomics pediatrics physiology pathology TCM syndrome |
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