Protection of the flowers ofPrunus persica extract from ultraviolet B-induced damage of normal human keratinocytes |
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Authors: | Young Ha Kim Hye Eun Yang Jong Ha Kim Moon Young Heo Hyun Pyo Kim |
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Affiliation: | College of Pharmacy, Kangwon National University, Chunchon, Korea. |
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Abstract: | For an attempt to develop safe materials protecting solar ultraviolet (UV)-induced skin damage, plant extracts were evaluated for their inhibitory activities of free radical generation and arachidonic acid/metabolites release from UVB-irradiated normal human keratinocytes. From the results of these screening procedures, the ethanol extract of the flowers of Prunus persica (Ku-35) was selected for further study. It was found that Ku-35 (100-1,000 microg/ml) inhibited the amount of 14C-arachidonic acid/metabolites release from UVB-irradiated keratinocytes. It was also demonstrated that Ku-35 possessed the protective activity against UV-induced cytotoxicity of keratinocytes and fibroblasts. In addition, Ku-35 was revealed to protect UVB-induced erythema formation using guinea pigs in preliminary in vivo study. All these results indicate that the flowers of P. persica extract may be beneficial for protecting UV-induced skin damage when topically applied. |
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Keywords: | UV-induced skin damage Flowers ofPrunus persica (Rosaceae) Human keratinocyte Arachidonic acid Erythema |
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