冠心病病人血清可溶性白细胞介素－2受体水平及T淋巴细胞亚群的变化

采用双抗体夹心法和碱性磷酸酶抗碱性磷酸酶法检测了８４例冠心病病人血清可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）水平和外周血Ｔ淋巴细胞亚群（ＣＤ４，ＣＤ８）的变化。结果显示，冠心病病人血清ｓＩＬ－２Ｒ水平明显高于对照组（Ｐ＜０．００１）；ＣＤ４，ＣＤ４／ＣＤ８明显降低，而ＣＤ８明显增高，与对照组相比差异有极显著意义（Ｐ＜０．００１），且急性心肌梗塞（ＡＭＩ）的变化较不稳定心绞痛（ＵＡ）和陈旧性心肌梗塞（ＯＭＩ）更明显。１周内病死的ＡＭＩ病人ｓＩＬ－２Ｒ和ＣＤ８的增高及ＣＤ４和ＣＤ４／ＣＤ８降低较存活者更明显（Ｐ＜０．００１）。提示血清ｓＩＬ－２Ｒ水平和Ｔ淋巴细胞亚群异常与冠心病的病情和预后有密切关系。

CHANGES IN LEVELS OF SERUM SOLUBLE INTERLEUKIN-2 RECEPTOR AND T-LYMPHOCYTE SUBPOPULATION IN PATIENTS WITH CORONARY HEART DISEASE

The level of the serum soluble interleukin-2 receptor(sIL-2R)and the frequency of the T-lymphocite subpopulation(CD4,CD8)were determined by the sandwiched ELISA and alkaline phosphatase-antialkaline phosphatase(APAAP)methods in patients with coronary heart disease(CHD). The results showed that the slL-2R level was significantly higher(P<0.001), the CD4 level and CD4/CD8 ratio significantly lower, and the CD8level significantly higher(P<0.001)in CHD patients than in normals. These abnormalities were more obvious in acute myocardial infarction(AMI)than in unstable angina (UA)and old myocardial infarction(OML), and more obvious in AMI patients who died within a week of hospitalization than in the survivals(P<0.001). These results indicate that the serum sIL-2R level and the T-lymphocyte subpopulation are closely related to the patient's condition and the prognosis of the disease.