IL-6、IL-8在不同潮气量单肺通气肺癌根治术中的表达

目的观察在肺癌根治术中不同潮气量(VT)的单肺通气(OLV)对血IL-6、IL-8表达的影响。方法 30例行肺癌根治术患者,用随机数字表法分为3组。行双腔支气管插管麻醉,术中单肺通气期间在保持分钟通气量不变的情况下,A组VT=10 ml/kg,呼吸频率(f)=12次/min,B组VT=8 ml/kg,f=15次/min,C组VT=6 ml/kg,f=20次/min。在OLV前(T1)、OLV后30 min(T2)、60 min(T3)、OLV结束前(T4)检测血IL-6、IL-8的表达。结果 3组在T2、T3、T4时点的IL-6、IL-8表达均明显高于T1(P<0.05),且随OLV时间延长而逐渐升高;OLV后随设定的潮气量减低,IL-6及IL-8表达逐渐降低;A组的IL-6、IL-8表达显著高于B、C组(P<0.05)。结论在单肺通气的肺癌根治术中,采用小潮气量的通气模式可减少肺内炎症反应。

Effect of One-lung Ventilation of Different Tidal Volume on the Expressions of Interleukin-6 and Interleukin-8 in Lung Cancer Patients during Radical Operation

Objective To study effect of one-lung ventilation(OLV) of different tidal volume(VT) on the expressions of serum interleukin-6(IL-6) and interleukin-8(IL-8) in lung cancer patients during radical operation.Methods Thirty lung cancer patients undergoing radical operation were enrolled in the study.All the patients received double-lumen endobronchial intubation anesthesia,and were randomly divided into three groups after one-lung ventilation during radical operation:Group A(VT=10 ml/kg,respiratory frequency(f)=12/min),Group B(VT=8 ml/kg,f=12/min),Group C(VT=6 ml/kg,f=12/min).The expressions of serum IL-6,IL-8 were detected before OLV(T1),30 min after OLV(T2),60 min after OLV(T3),1 min before OLV ending(T4).Results Compared with T1,the expressions of IL-6,IL-8 on T2,T3,T4 significantly increased in three groups(P<0.05),and the increase was in a time-dependent manner.The expressions of IL-6,IL-8 gradually decreased with VT reduction during OLV.The expressions of IL-6,IL-8 in Group A were significantly higher than those in Group B,C(P<0.05).Conclusion The ventilation mode of low tidal volume can reduce the pulmonary inflammatory response in radical operation for lung cancer with one-lung ventilation.