急性胰腺炎患者微循环障碍的动态变化

目的观察急性胰腺炎(AP)患者微循环障碍与病情变化的关系。方法轻型AP(MAP组)、重症AP(SAP组)、单纯胆囊炎胆囊结石(对照组)患者各20例,MAP组和SAP组于入院后第1、3、7天,对照组于入院后第1天检测凝血功能及血液流变学指标。结果 SAP组第1、3天凝血酶原时间、部分活化凝血酶原时间、纤维蛋白原含量和D-二聚体含量均高于MAP组,两组均高于对照组(P<0.05)。SAP组第1、3、7天血小板计数均低于MAP组和对照组(P<0.05)。MAP组全血黏度指标均高于对照组,SAP组高于MAP组(P<0.05)。结论凝血功能及血液流变学指标与AP病情相关,动态监测凝血功能及血液流变学指标有助于评估AP病情的发展与转归。

Dynamic changes of microcirculatory disturbance in patients with acute pancreatitis

Objective To investigate the relationship between microcirculatory disturbance and change of disease condition in patients with acute pancreatitis(AP). Methods Coagulation profile and hemorheological indexes were detected in 20 patients with mild AP(group MAP) and 20 patients with severe AP(group SAP) on the 1st,3rd and 7th day after admission,which were examined in 20 cases with cholecystitis or cholecystolithiasis(group C) on the 1st day after admission. Results The prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB) concentration and D-dimer(D-D) concentration were higher in group SAP than those in group MAP on the 1st and 3rd day, which of both groups were higher than those in group C(P<0.05).Platelet count was lower in group SAP than that in groups of MAP and C on the 1st,3rd and 7th day(P<0.05). The viscosity of whole blood was higher in group MAP than that in group C,which was higher in group SAP than that in group MAP on the 1st,3rd and 7th day(P<0.05). Conclusion The coagulation profile and hemorheological indexes are related to disease condition of AP.Dynamically montoring coagulation and hemorheological criteria is helpful to evaluate the prognosis of AP.