糖尿病前期人群血清尿酸水平与胰岛素敏感性的关系

目的探讨糖尿病前期人群血尿酸水平与胰岛素敏感性的关系。方法 900例糖尿病前期患者(男451例,女449例),根据血尿酸水平将男女患者分别分为高尿酸组(HUA组)和正常尿酸组(NUA组)。75g口服葡萄糖耐量试验(OGTT)及胰岛素释放试验在0、30、120min分别测定血糖和胰岛素。用Matsuda胰岛素敏感性指数(Matsuda ISI)评估胰岛素敏感性。多重线性回归分析血清尿酸与胰岛素敏感性的关系。结果在男性和总体人群中,HUA组在OGTT各时间点的胰岛素、C-肽水平高于NUA组,而Matsuda ISI低于NUA组。在性别分组及控制了年龄、吸烟、饮酒、体重指数、甘油三酯、高密度脂蛋白胆固醇、肌酐、糖化血红蛋白等因素前、后,血清尿酸与Matsuda ISI均存在负线性关系。结论糖尿病前期人群血清尿酸水平与胰岛素敏感性独立相关,尿酸水平越高胰岛素敏感性越低。

Relationship between serum uric acid and insulin sensitivity in prediabetes

Objective To explore the relationship between serum uric acid(UA) and insulin sensitivity in the prediabetes. Methods A total of 900 prediabetes(451 males,449 females) was divided into groups of HUA(hyperuricemic) and NUA(nonhyperuricemic).Venous blood was sampled at 0,30 and 120 min of oral glucose tolerance test to measure glucose and insulin concentration.Matsuda insulin sensitivity index(Matsuda ISI) was calcultated to access insulin sensitivity.Multiple linear regression was used to analyze the relationship between serum UA and insulin sensitivity. Results Compared to subjects in group NUA,the people of total population and males with HUA had higher leveles of serum insulin,C-peptide and lower Matsuda ISI.There was a negative linear correlation between serum UA and Matsuda ISI before or after controling the factors of sex,age,smoking,alcohol drinking,body mass index(BMI),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),serum creatinine and glycated haemoglobin(HbA1c). Conclusion In the prediabetes,there is an independent correlation between serum UA and insulin sensitivity.The higher serum UA is,the lower insulin sensitivity is.