三七对高脂血症家兔血浆TXB2、GMP-140含量的影响

目的探讨三七粉对高脂血症家兔的降脂作用及对血浆血栓烷B2(TXB2)、α-颗粒膜蛋白140(GMP-140)含量的影响。方法 18只健康家兔随机均分为高脂血症组(A组)、高脂血症治疗组(B组)和对照组(C组)。A、B组饲喂高脂饲料,C组饲喂普通饲料,共6周。第3周开始,B组灌服三七粉0.23g.kg-1.d-1,A、C组灌以等体积的生理盐水。分别于实验前、第3、6周时检测血清中甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)水平,第6周时检测血浆中TXB2、GMP-140含量。结果与A组相比,第6周时B组血清TG、HDL-C水平明显下降(P<0.05),血浆TXB2、GMP-140含量显著降低(P<0.01)。结论三七能降低血脂,抑制TXB2、GMP-140表达,对动脉粥样硬化和血栓性心脑血管疾病有较好的防治作用。

Effect of pseudoginseng on the contents of TXB2 and GMP-140 in plasma of experimental hyperlipidemic rabbit

Objective To investigate the effect of pseudoginseng on serum lipids and contents of thromboxane B2(TXB2) and granule membrane protein-140(GMP-140) in plasma of the experimental hyperlipidemic rabbits.Methods Eighteen healthy rabbits were equally randomized into three groups of B(fed with hyperlipemia diet for 6 weeks and administrated with pseudoginseng 0.23 g·kg-1·d-1 from the beginning of the 3rd week),A(fed with hyperlipemia diet for 6 weeks and given same volume of normal saline) and C(fed with normal diet for 6 weeks and given same volume of normal saline).The levels of triglycerides(TG),total cholesterol(TC),high-density lipoproteins cholesterol(HDL-C) in serum were detected before experiment and on the 3rd,6th week.The contents of TXB2,GMP-140 in plasma were detected on the 6th week.Results Compared with group A,the levels of TG,HDL-C in serum and contents of TXB2,GMP-140 in plasma were decreased in group B on the 6th week(P<0.05).Conclusion Pseudoginseng is able to reduce serum lipids and plasma TXB2,GMP-140 levels,which can prevent and cure atherosclerosis and thrombotic cardio-cerebrovascular diseases.