极低出生体重儿撤机后应用NCPAP的临床研究

目的探讨极低出生体重儿机械通气撤机后应用新型鼻塞持续气道正压通气（nasal continuous positive airway pressure，NCPAP）后的治疗效果。方法治疗组为33例极低出生体重儿拔管后采用NCPAP，对照组为29例极低出生体重儿拔管后后采用头罩吸氧。比较两组的有创通气时间、总氧疗时间、总住院天数、撤机成功率、肺气漏。结果治疗组与对照组有创通气时间分别为（127±70．2）h和（156±65．5）h（P〈0．05），治疗组与对照组撤机成功率分别是84．9％和68．9％（P〈0．05），两组的氧疗时间、住院天数、肺气漏等发生无明显差异（P〉0．05）。结论极低体重儿有创通气撤机后使用NCPAP，可以减少有创通气时间，提高撤机成功率。

Application of nasal continuous positive airway pressure in very low birth weight infants after weaning ventilator

Objective To explore the therapeutic effect of nasal continuous positive airway pressure (NCPAP)in very low birth weight infants after weaning ventilator.Methods 33 very low birth weight infants in experimental group accepted NCPAP,29 very low birth weight infants in control group accepted O2 via head box.The two groups were compared by the duration of invasive ventilation,time of oxygen requirement,hospital stay,the weaning success rate and the ineidence lung frequent hemorrhoid.Results The duration of invasive ventilation in experimental group and control group was respectively(127±70.2)h and(156±65.5)h(P＜0.05).The weaning success rate was 84.9%in therapy group versus 68.9%in control group(P＜0.05).there were no increase in time of oxygen requirement,hospital stay and the incidence lung frequent hemorrhoid.Conclusion NCPAP iannediately after weaning ventilator may decrease the duration of invasive ventilation and incresge the weaning success rate.