莲菊感冒胶囊长期毒性实验研究

目的：观察莲菊感冒胶囊对大鼠长期给药可能产生的毒性反应,为临床应用提供毒理学依据。方法：取88只Wistar大鼠,随机分为莲菊感冒胶囊高、中、低剂量组（以生药计分别为2.5、1.25、0.625 g/kg）和对照组,给药组连续给药13周,对照组给等容量蒸馏水;观察两组大鼠的一般状况、体重、摄食量,测定第13周及给药组大鼠停药后2周的血液生化指标,脏器系数、解剖学及病理组织学改变。结果：莲菊感冒胶囊各组动物一般状况良好,体重增长、脏器系数、血常规、血液生化指标、解剖学和主要脏器的病理组织学检查均正常,与对照组比较无明显差异。结论：莲菊感冒胶囊在临床剂量范围内毒性小,使用安全。

A Study on Long-Term Toxicity of Lianju Ganmao Capsule

Objective: To observe long-term toxicity of Lianju Ganmao Capsule,so as to provide toxicological basis for clinical medication.Methods: Eighty-eight Wistar rats were randomly divided into 4 groups(22 in each).Groups H,M,L were orally given high,moderate,or low dosages(2.5,1.25,and 0.625 g/kg) of Lianju Ganmao Capsule respectively,and control group(group C) were given distilled water instead.The experiment was carried out for 13 consecutive weeks.General conditions,body weight and food intake of rats were ob...