异甘草酸镁联合多烯磷酯酰胆碱治疗对慢性乙型肝炎患者血清细胞因子的影响和疗效观察

目的 探讨异甘草酸镁联合多烯磷酯酰胆碱注射液对慢性乙型肝炎患者的治疗疗效及其对血清细胞因子的影响。方法 随机选择2015年1月~2016年6月陕西省铜川市人民医院感染病科收治的慢性乙型肝炎患者80例,随机分为对照组和治疗组,每组40例。给予观察组患者多烯磷脂酰胆碱注射液治疗,治疗组则在对照组的基础上加用异甘草酸镁注射液治疗,疗程均为4 w。采用酶联免疫吸附法测定血清细胞因子水平。结果 在治疗4 w末,治疗组血清肿瘤坏死因子-α、白细胞介素-2（IL-2）、IL-4、IL-10水平分别为（4.2±1.6） ng/L、（197.5±21.7）ng/L、（34.9±4.9） ng/L和（15.7±2.8） ng/L,较对照组的【（6.3±2.2） ng/L、（164.1±18.6） ng/L、（53.6±6.6） ng/L和（28.6±4.2） ng/L】均有明显改善（P<0.05）;治疗组血清丙氨酸氨基转移酶、总红胆素和凝血酶原时间国际标准化比值分别为（39.8±7.6） U/L、（22.9±3.6） μmol/L和（1.2±0.1）,显著低于对照组的[（76.6±11.3） U/L、（30.5±3.9）μmol/L和（1.4±0.2）,P<0.05]。结论 异甘草酸镁联合多烯磷脂酰胆碱治疗慢性乙型肝炎患者有益于改善血清细胞因子水平和肝功能状态。

Effects of magnesium isoglycyrrhizinate combined with polyene phosphatidylcholine on serum cytokines in patients with chronic hepatitis B

Objective To investigate the effects of magnesium isoglycyrrhizinate combined with polyene phosphatidylcholine on serum cytokines in patients with chronic hepatitis B. Methods Eighty patients with chronic hepatitis B were admitted into our hospital between January 2015 and June 2016,and they were divided randomly into control and treatment group with forty cases in each group. Patients in control group were treated with polyene phosphatidylcholine,and those in treatment group were treated with magnesium isoglycyrrhizinate combined with polyene phosphatidylcholine. The regimen lasted for 4 weeks in both groups. The levels of serum cytokine were assayed by ELISA. Results At the end 4 weeks of treatment,serum tumor necrosis factor-α, interleukin-2 （IL-2）,L-4 and IL-10 in combination patients were （4.2±1.6） ng/L,（197.5±21.7） ng/L,（34.9±4.9） ng/L and （15.7±2.8） ng/L,respectively,obviously improved as compared with those in the control group [（6.3±2.2） ng/L,（164.1±18.6） ng/L,（53.6±6.6） ng/L,（28.6±4.2） ng/L,respectively,P<0.05 for all];serum alanine aminotransferase,total bilirubin,and international normalized ratio of prothrombin time in combination group were significantly lower than those in control group [（39.8±7.6） U/L vs. （76.6±11.3） U/L,（22.9±3.6） μmol/L vs. （30.5±3.9） μmol/L,and（1.2±0.1） vs.（1.4±0.2）,P<0.05 for all]. Conclusion Magnesium isoglycyrrhizinate combined with polyene phosphatidylcholine can improve clinical outcomes in patients with chronic hepatitis B,especially in decreasing serum levels of cytokines and liver function index.