超声引导下经皮射频消融与激光消融治疗微小肝癌患者疗效初步比较研究

目的 比较超声引导下经皮激光消融（LA）与经皮射频消融（RFA）治疗微小肝癌患者的临床疗效。方法 54例微小（<2 cm）肝癌患者被分为LA组和RFA组,每组27例。比较两组疗效、肿瘤局部控制（LC）和无进展生存时间（PFS）。结果 LA组近期有效率（RR）为81.5%,与RFA组的77.8%比,差异无统计学意义（P>0.05）;RFA组一年LC为77.8%,显著高于LA组的51.9%,差异有统计学意义（P<0.05）; RFA组PFS为（12.5±6.6）个月,显著长于LA组的（8.7±5.1）个月,差异有统计学意义（P<0.05）;两组术后局部疼痛、腹腔出血、胆道出血和腹腔感染等并发症发生率无显著性相差（P>0.05）。结论 与LA治疗比,RFA可提高治疗微小HCC患者的肿瘤局部控制率,并延长患者的肿瘤无进展生存时间,具有一定的临床应用价值。

Comparison of ultrasound-guided percutaneous laser ablation and radiofrequency ablation for the treatment of patients with small hepatocellular carcinoma

Objective To compare the efficacies of ultrasound-guided percutaneous laser ablation （LA） and radiofrequency ablation （RFA） for the treatment of patients with small hepatocellular carcinoma （HCC）. Methods We retrospectively analyzed the data of 54 patients with small HCC admitted to our department between 2010 and 2014. The patients with HCC were randomly divided into LA （n=27） and RFA group （n=27）. The response rates （RR）,local control （LC） rates and progression free survival （PFS） between the two groups were compared. Results The RR in LA group was 81.5%,not statistically significantly different compared with 77.8% （P>0.05） in the RFA group;The LC at the end of one year in RFA group was 77.8%,significantly higher than 51.9% in LA group （P<0.05）;The PFS in RFA group was （12.5±6.6） months,significantly longer than （8.7±5.1） months in LA group（P<0.05）;There was no significant difference as respect to the incidence of postoperative complications （P>0.05）. Conclusions RFA can improve LC,and prolong PFS in patients with small HCC,which warrants further clinical application.