医院内尿路感染病原菌的监测及耐药性分析

目的探讨医院内尿路感染病原菌的分布情况及耐药特征,为临床合理选用抗菌药物提供依据。方法收集2003年1月-2005年12月住院患者发生尿路感染的标本中分离的272株病原菌,进行细菌鉴定和药敏试验,并对革兰阴性杆菌进行ESBLs的检测。结果尿路感染病原菌以革兰阴性杆菌为主(68.4%),革兰阳性球菌为19.1%,真菌为12.5%;产ESBLs大肠埃希菌的检出率为41.1%,产ESBLs肺炎克雷伯菌的检出率为18.2%。结论革兰阴性杆菌是尿路感染的主要病原菌,病原菌的耐药率呈上升趋势;重视病原菌的监测和耐药性分析,对指导临床合理使用抗菌药物,控制医院感染具有重要意义。

Distribution of Pathogens and Resistance Detection in Urinary Infection

OBJECTIVE To determine distribution of pathogens and resistance characteristic in urinary infection and to provide basis for clinicians to select antibiotics correctly.METHODS A total of 272 strains of pathogens were identified and ESBLs-producing G-bacilli were detected.RESULTS Among 272 strains,68.4% of G-bacilli,19.1% of G cocci,12.5% of fungi,41.1% of Escherichia coli and 18.2% of Klebsiella pneumoniae strains produced ESBLs.CONCLUSIONS G-bacilli are major pathogens of urinary infection and their resistance is raised.Much attention should be paid to resistance detection.It is important to control nosocomial infection and select antibiotics correctly.