磷脂酰肌醇生物合成通路中的新肿瘤抑制基因INPP4B

磷脂酰肌醇信号通路参与许多的癌症和其他疾病发生发展。该通路中存在多个肿瘤相关基因，其中抑癌基因PTEN、癌基因 PI3K是被广泛研究的两个基因。最近这条通路中的另一个磷脂酰磷酸酶，磷脂酰肌醇4-磷酸酶Ⅱ型（INPP4B），被证实是一个潜在的肿瘤抑制基因，其在前列腺癌、乳腺癌中低表达或突变，与该疾病的发生、预后相关。该文重点阐述了 INPP4B的分子结构和功能，及其介导的 Akt-mTOR 信号传导通路，与 PTEN 的协同作用及与几种肿瘤的相关性，并探讨 INPP4B 在细胞核内维护基因组稳定性的潜在作用。总之，对 INPP4B的深入研究不仅为磷脂酰肌醇信号调控肿瘤发生提供了新机制，而且为抗肿瘤药物研究提供了有价值的分子靶点。

INPP4 B,a new tumor suppressor in the biosynthesis pathway of phosphatidyl inositol

Phosphatidyl inositol signaling pathway is involved in the occurrence and development of many cancers and other diseases .The tumor suppressor PTEN and oncogene PI 3 K are the best known tumor related genes in this signaling pathway .Recently , another lipid phosphatase , Inositol polyphosphate 4-phosphatase type Ⅱ （ INPP 4 B ） , has emerged as a potential tumor suppressor in prostate , breast , and other malignancies .Mutation or low expression of INPP 4 B has been closely related to the poor prognosis of these cancers .In this review , we focused on the structure and enzymatic functions of INPP 4 B , its in-volved Akt-mTOR signaling pathway , connection to PTEN , correlation with the development of several tumors , as well as its potential nuclear role in maintaining genomic stability .Taken together , the new ad-vances of INPP 4 B research will shed new light no tumorigenic mechanisms underlying the biosynthesis of inositol phosphate , and will offer novel potential therapeutic targets for cancer treatment .