肝炎后肝硬化患者血清NO和NOS的变化

目的 研究肝炎后肝硬化患者血清一氧化氮（NO）及一所为合酶（NOS）水平的变化，方法 实验组：肝硬化患者58例；对照组：正常健康者40例。血清学检测指标：NO、NOS含量、血清丙氨酸氨基转移酶（ALT）、血清胆红素（SB）、清蛋白（ALB）及血浆凝血酶原活动度（PTA）。结果 肝硬化Child-Pugh C级患者血清NO明显增高，与Child-Pugh A级及正常对照组比较有显著性差异（P＜0.05）；而血汪有NOS降低，与正常对照组及Child-Pugh A、B级比较均有显著性差别（P＜0.05）。结论 血清NO水平随肝硬化Child-Pugh分级增加而增高，而血清NOS却呈负增加现象。

Modification of Serum Levels of Nitric Oxide and Nitric Oxide Synthase in Patients with Posthepatitic Cirrhosis

Objective To study the change and correlation between serum nitric oxide (NO) and nitric oxide synthase (NOS) in patients with hepatic cirrhosis. Methods The experiment group consisted of 58 patients with hepatic cirrhosis and the control group 40 healthy people. Tests included NO, NOS, alanine transaminase (ALT), serum total bilirubin (SB), albumin (ALB), and serum pro- thrombin activity (PTA) determination. Results Serum NO in sera of liver cirrhosis patients in- creased with the decline of hepatic function especially in Child - Pugh C grade. There was significant difference between the experiment group and the control group (P < 0.05). However, compared with the control group the patients' serum NOS level decreased significantly as hepatic function was increasingly impaired (P < 0.05). Conclusion Hepatic function becomes graver, the higher serum NO level in the lower serum NOS level.