阿尔茨海默病与神经生长因子的基因治疗

基因治疗在阿尔茨海默病(Alzheimer’s disease，AD)中具有重要的意义。近年来，基因治疗载体的研究从腺 病毒载体、腺相关病毒载体和慢病毒载体逐渐转移至脂质体及纳米材料载体系统，纳米材料载体系统中的最新成员 石墨烯载体更是因其具备良好的通透性和生物相容性而受到广泛的关注。基因治疗的方法分为直接法和间接法，目 前研究较多的干细胞疗法属于间接法。在AD的基因治疗中，选择合适的载体与方法将为治疗带来更好的效果。

Alzheimer’s disease and nerve growth factor gene therapy

Gene therapy plays an important role in Alzheimer's disease (AD). In recent years, the research on gene delivery vector has gradually transferred from adenovirus vector, adeno-associated virus vector and lentivirus vector to liposomes and nanomaterial carrier systems. Graphene, the newest member of nanomaterial carrier system, has att racted extensive att ention for its well permeability and biocompatibility. Th e methods of gene therapy can be divided into direct and indirect method. Th e stem cell therapy, which is the most-well studied one, belongs to the indirect method. In the gene therapy of AD, the selection of appropriate carrier and method will determine the therapeutic eff ect.