Research progress for delamanid resistance mechanism of Mycobacterium tuberculosis |
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| Authors: | LIU Yuan-yuan CHU Ping HAN Shu-jing YANG Hui LU Jie |
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| Affiliation: | Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China |
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| Abstract: | At present, tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is still the leading cause of death for infectious diseases worldwide. The spread of drug-resistant strains has caused great difficulties in the treatment of TB. Delamanid (Dlm), a new anti-TB drug, is effective against multi-drug resistant (MDR) or extensively drug-resistant (XDR) tuberculosis. Accurate and timely detection of Dlm-resistant strains can maximize the effectiveness of clinical application for the drug and improve the cure rate of MDR-TB/XDR-TB. The acquired drug resistance in MTB is mainly caused by resistance associated gene mutations. This article reviews the resistance mechanism and resistance associated gene mutations of Dlm, to provide some reference for the early molecular diagnosis of Dlm-resistant strains. |
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| Keywords: | Mycobacterium tuberculosis Delamanid Drug resistance Molecular mechanisms of pharmacological action Point mutation Review literature as topic |
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