| Chymase在肺动脉高压疾病的肺动脉重构中的表达 |
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| 引用本文： | 韩素霞,黄强,文富强. Chymase在肺动脉高压疾病的肺动脉重构中的表达[J]. 地方病通报, 2009, 0(3): 26-27 |
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| 作者姓名： | 韩素霞 黄强 文富强 |
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| 作者单位： | 新疆医科大学第五附属医院; |
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| 摘 要： | 目的探讨了慢性香烟暴露诱导的PAH病变过程中仓鼠肺组织chymase的表达变化。方法将12只雄性仓鼠随机分为：对照组、香烟暴露组；仓鼠暴露于香烟烟雾中4个月建立肺动脉高压模型；免疫组织化学染色法检测肺小动脉中chymase的蛋白表达。结果Chymase在香烟暴露组仓鼠的肺小动脉中的表达增加，尤其在肺小动脉外膜及增生的内皮细胞中，染色呈强阳性。结论随着肺结构的改变，香烟暴露可刺激chymase的表达增加，表明chymase在PAH中肺小动脉的重构病变中起作用，因此，抑制chymase的形成将有助于阻止香烟诱导的肺动脉高压疾病的发生、发展。
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| 关 键 词： | 香烟 肺动脉高压 Chymase |
Expression of Chymase in Pulmonary Artery Reconstruction of Pulmonary Hypertension |
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| HAN Su-xia,HUANG Qiang,WEN Fu-qiang. Expression of Chymase in Pulmonary Artery Reconstruction of Pulmonary Hypertension[J]. Endemic Diseases Bulletin, 2009, 0(3): 26-27 |
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| Authors: | HAN Su-xia HUANG Qiang WEN Fu-qiang |
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| Affiliation: | HAN Su-xia1,HUANG Qiang1,WEN Fu-qiang2(The 5th Affiliated Hospital of Xinjiang Medical University,Uruqmi,Xinjiang 830011,China) |
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| Abstract: | Objective To study the expression of chymase in pulmonary tissue of hamster during pulmonary hypertension(PAH) in pathological changes induced by chronic exposure to cigarette smoke.Methods In this study,12 hamsters were randomly divided into 2 groups of control and smoke exposure.After the exposure for 4 months,the hamsters were collected to establish model of pulmonary hypertension,and the protein expression of chymase in pulmonary artery was detected with immunohistochemichal stain.Results The levels of ... |
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| Keywords: | Cigarette smoke Pulmonary hypertension(PAH) Chymase |
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