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| 精子蛋白SP22研究进展 | |
| 引用本文： | 宛传丹,黄宇烽,许晓风. 精子蛋白SP22研究进展[J]. 中华男科学杂志, 2005, 11(1): 56-59 |
| 作者姓名： | 宛传丹 黄宇烽 许晓风 |
| 作者单位： | 1. 南京军区南京总医院生殖遗传研究室,江苏,南京,210002;南京师范大学生命科学院,江苏,南京,210097 2. 南京军区南京总医院生殖遗传研究室,江苏,南京,210002 3. 南京师范大学生命科学院,江苏,南京,210097 |
| 摘 要： | 精子蛋白SP22是一种与多种疾病相关并广泛表达于各种组织的多功能蛋白。SP22定位于精子表面,具有酶活性,能够辅助精子穿入卵子,在ras因子共同作用下具有致癌活性。各物种中SP22高度保守,说明它对生命的重要性。目前对SP22与男性不育、帕金森病的关系研究较多。本文综述了SP22在基因结构、蛋白结构、功能特性等方面的最新研究进展。 |
| 关 键 词： | SP22 生殖 致癌 |
| 文章编号： | 1009-3591(2005)01-0056-04 |
| 修稿时间： | 2004-03-31 |
Advances in the Studies of Sperm Protein 22 (SP22) |
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| WAN Chuan-dan ,,HUANG Yu-feng ,XU Xiao-feng .Laboratory of Reproduction , Genetics,Nanjing General Hospital of Nanjing Command,PLA,Nanjing,Jiangsu ,China, .College of Life Science,Nanjing Normal University,Nanjing,Jiangsu ,China. Advances in the Studies of Sperm Protein 22 (SP22)[J]. National journal of andrology, 2005, 11(1): 56-59 | |
| Authors: | WAN Chuan-dan HUANG Yu-feng XU Xiao-feng .Laboratory of Reproduction & Genetics Nanjing General Hospital of Nanjing Command PLA Nanjing Jiangsu China .College of Life Science Nanjing Normal University Nanjing Jiangsu China |
| Affiliation: | Laboratory of Reproduction & Genetics, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China. |
| Abstract: | Multifunctional sperm protein 22(SP22) is expressed ubiquitously and related to quite a few diseases. Located on the sperm surface, SP22 has an enzymatic activity that may assist sperm in penetrating into the ovum. SP22 may be carcinogenic in compiracy with the factor ras. Among all species SP22 is highly conservative, which demonstrates its importance to life. More and more studies indicate that SP22 is directly correlated with male infertility and Parkinson's disease. This article summarizes recent researches on SP22 in the gene structure, protein structure and functional characteristics. |
| Keywords: | SP22 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |