Low triiodothyronine and cardiomyopathy in patients with end-stage renal disease |
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| Authors: | Zoccali Carmine Benedetto Francesco Mallamaci Francesca Tripepi Giovanni Cutrupi Sebastiano Pizzini Patrizia Malatino Lorenzo Salvatore Bonanno Graziella Seminara Giuseppe |
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| Institution: | CNR-IBIM, Institute of Biomedicine, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension & Division of Nephrology, Reggio Calabria, Italy. carmine.zoccali@tin.it |
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| Abstract: | OBJECTIVES AND METHODS: Low free plasma triiodothyronine (fT3) is associated with inflammation and cardiovascular damage in patients with end-stage renal disease (ESRD). We investigated the relationship between fT3, left ventricular systolic function and left ventricular mass in a group of 234 dialysis patients, and modelled the association between fT3 and cardiomyopathy in statistical analyses including both direct (interleukin-6 and C-reactive protein) and inverse (serum albumin) acute phase inflammation markers. RESULTS: Plasma fT3 concentration in dialysis patients was significantly (P < 0.001) reduced in comparison with healthy participants and clinically euthyroid patients with normal renal function. Left ventricular systolic function was depressed (P
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