胸腺蛋白治疗消化性溃疡出血的疗效观察

目的观察胸腺蛋白对消化性溃疡出血的治疗及预防复发作用。方法将185例消化性溃疡合并上消化道出血的患者随机分为单纯奥美拉叹组和奥美拉唑＋胸腺蛋白组，每组分别为91例和94例。统计分析两组消化性溃疡出血的平均止血时间、治疗有效率及随访1年的出血复发率。结果奥美拉唑＋胸腺蛋白组与单纯奥美拉唑组比较，胃溃疡出血的平均止血时间下降有非常显著差异（P＜0．01）；而十二指肠球部溃疡出血的平均止血时间下降有显著差异（P＜0．05）。治疗胃溃疡出血、十二指肠球部溃疡出血的有效率无显著差异（P＜0．05）；但胃溃疡出血及十二指肠球部溃疡出血1年复发率下降分别有显著差异（P＜0．05）和非常显著差异（P＜0．01）。结论胸腺蛋白有缩短消化性溃疡出血的止血时间及预防出血复发作用。

Clinical observation of therapeutic effect of thymic protein (TP)on peptic ulcer hemorrhage

Objective To observe the therapeutic and recurrence prophylactic effects of thymic protein on peptic ulcer hemorrhage .Methods 185 patients with peptic ulcer and upper gastrointestinal tract bleeding were randomly divided into two groups :the first group of 91cases were treated with omeprazole (OME) only and the second group of 94 cases with OME TP. The average time of stopping bleeding the therapeutic effective rate and the one -year recurrence rate were analyzed by statistics .Results Compared with the OME group ,the average time of stopping bleeding in the OME TP group was very markedly reduced (P < 0.01 ) in gastric ulcer and markedly reduced (P < 0.05)comparing to OME, therecurrence rate in gastric and duodenal rlcer hemorrhage were significantly (P < 0.05) and very significantly (P < 0.01 ) decreased respectively . Conclusion TP has the effects of cutting the time of stopping bieeding in peptic ulcer hemorrhage and preventing its recurrence .