内皮微粒与冠心病相关性研究

目的:探讨血浆内皮微粒(EMP)与冠心病的相关性。方法:冠心病组367例,其中稳定型心绞痛(SA)119例,急性冠状动脉综合征(ACS)248例,后者含不稳定型心绞痛(UA)158例,急性心肌梗死(AMI)90例。非冠心病组166例。ELISA法测定血浆ET-1,流式微球技术检测血浆EMP。结果:冠心病组ET-1、EMP水平升高,呈正相关(r=0.233,P=0.001)。ACS组EMP(547.405)显著高于非冠心病组(148.185)及SA组(429.890),亚组分析中UA组EMP(551.660)升高最为显著;冠心病冠状动脉病变支数与EMP无明显相关;AMI患者EMP与BNP、TnT、TnI间无明显相关;EMP与ACS患者短期预后相关(r=0.280,P<0.01)。结论:血浆EMP水平可反映冠心病内皮功能障碍,与冠心病的发生、冠状动脉斑块的不稳定性有关。

Correlationship of endothelial microparticles and coronary heart disease

Objective:To study the expression of endothelial microparticles(EMP) in coronary heart disease(CHD) and the relationship of EMP and the severity of CHD.Method: 367 patients with CHD were enrolled(119 patients were stable angina(SA) group,248 patients were acute coronary syndrome(ACS) group,including unstable angina UA 158 and acute myocardial infarction 90).Besides,166 coronary negative patients were included as control.ELISA was used to detect plasma ET-1 levels and Cytometric Bead Assay(CBA) to detect plasma EMP levels.Result:The levels of ET-1 and EMP were elevated in CHD group with a positive correlation(r=0.233,P=0.001).The EMP level in ACS(547.405) was significantly higher than control group(148.185) and SA group (429.890).The EMP levelin UA subgroup was the highest.There was no obvious relationship between EMP and the stability of coronary lesions in CHD group.And also no obvious relationship between EMP and BNP,TnT,TnI in AMI group.The positive correlation was observed between EMP levels and short-term prog-nosis of ACS(r=0.280,P<0.01).Conclusion:Plasma EMP level reflected the endothelial dysfunction of CHD,and correlated to the occurrence of CHD and instability of coronary plaques.