| 混料均匀设计法在灯盏花素骨架片处方配比中的应用研究 |
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| 引用本文： | 刘清飞,罗国安,王义明.混料均匀设计法在灯盏花素骨架片处方配比中的应用研究[J].中成药,2006,28(5):632-635. |
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| 作者姓名： | 刘清飞 罗国安 王义明 |
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| 作者单位： | 清华大学医学院药物研究所,北京,100084 |
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| 基金项目： | 科技部十五攻关项目(2003BA310A18) |
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| 摘 要： | 目的:采用有约束混料均匀设计方法优化灯盏花素骨架缓释片中填充剂乳糖及阻滞剂HPMCSH4000与Carbopol 71 G的处方配比。方法:分别以单一因变量与综合因变量为指标,对不同处方进行评价,建立回归方程,求出综合最优解,从而筛选出最优处方。结果:两种方法筛选出的最佳配比较一致,所制得的片剂具有理想释药性能。结论:混料均匀设计较传统的均匀设计方法具有简单、直观、分布更为均匀的特点,适用于辅料用量固定的处方配比优化。
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| 关 键 词： | 灯盏花素 混料均匀设计 缓释片 |
| 文章编号： | 1001-1528（2006）05-0632-04 |
| 收稿时间： | 2005-05-18 |
| 修稿时间： | 2005-05-18 |
Optimization of breviscapin sustainded release tablets by mixture uniform design |
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| LIU Qing-fei,LUO Guo-an,WANG Yi-ming.Optimization of breviscapin sustainded release tablets by mixture uniform design[J].Chinese Traditional Patent Medicine,2006,28(5):632-635. |
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| Authors: | LIU Qing-fei LUO Guo-an WANG Yi-ming |
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| Institution: | Institute of Material Madica School of Medicine, Tsinghua University, Beijing 100084, China |
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| Abstract: | AIM: To optimize the excipient formulation of lactose,HPMC_(SH4000) and Carbopol 71 G in breviscapin sustained release tablets by mixture uniform design. METHODS: Different formulations,single factor f_2 and multifactors of cumulative release as index,were evaluated respectively. RESULTS: The optical formulations obtained by the two methods were identical,and the tablets with optical formulation had ideal sustained release. CONCLUSION: Mixture uniform design is simple,direct and uniform.It can be used in optimization of formulation with invariable amount. |
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| Keywords: | mixture uniform design breviscapin sustained release tablets |
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