| RANK/RANKL/OPG系统与肿瘤 |
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| 引用本文： | 李晓鸣,刘耀明,王志平.RANK/RANKL/OPG系统与肿瘤[J].国际病理科学与临床杂志,2009,29(3):259-262. |
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| 作者姓名： | 李晓鸣 刘耀明 王志平 |
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| 作者单位： | 1. 兰州大学第二医院泌尿外科研究所,兰州,730030
2. 兰州军区总医院安宁分院骨科,兰州,730070 |
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| 摘 要： | 胞核因子κB受体活化因子/细胞核因子κB受体活化因子配体/骨保护因子(RANK/RANKL/OPG)系统在破骨细胞的活化、发育、成熟过程中起关键性作用，近年研究发现该系统也广泛参与骨肿瘤发生、肿瘤骨转移、细胞凋亡，这些研究为相关疾病的治疗提供了新的思路和方法，如重组OPG和人类RANKL单克隆抗体AMG-162的应用。
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| 关 键 词： | 细胞核因子κB受体活化因子配体 细胞核因子κB受体活化因子 骨保护因子 肿瘤 |
| 收稿时间： | 2009-1-12 |
| 修稿时间： | 2009-6-19 |
RANK/RANKL/OPG system and tumor |
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| LI Xiaoming,LIU Yaoming,WANG Zhiping.RANK/RANKL/OPG system and tumor[J].Journal of International Pathology and Clinical Medicine,2009,29(3):259-262. |
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| Authors: | LI Xiaoming LIU Yaoming WANG Zhiping |
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| Institution: | 1.Institute of Urology Surgery, Second Hospital of Lanzhou University, Lanzhou 730030; 2.Department of Orthopaedics,Anning Branch of Lanzhou General Hospital, Lanzhou Command,PLA,Lanzhou 730070, China |
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| Abstract: | Receptor activator of nuclear factor-kappa B/ receptor activator of nuclear factor-kappa B ligand/ osteoprotegerin (RANK/RANKL/OPG) system plays the key role in Osteoclast’s activation，development and maturation process. Recent studies have demonstrated that it systemgenerally participates tumorigenesis，bony metastasis, and apoptosis. The progress in this field may present the new idea and strategy for therapy of related diseases. For example，recombinant OPG and AMG-162, the monoclonal antibody of RANKL, have been used. |
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| Keywords: | receptor activator of nuclear factor-kappa B ligand receptor activator of nuclear factor-kappa B osteoprotegerin tumour |
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