氟西汀联合奋乃静治疗精神病性抑郁症

目的 :研究氟西汀联合奋乃静治疗精神病性抑郁症 (PD)的疗效及其安全性。方法 :氟西汀联合奋乃静组 (简称氟西汀组 ) 2 9例 ,予以氟西汀 2 0mg ,po ,qd ;阿米替林联合奋乃静组 (简称阿米替林组 ) 2 8例 ,予以阿米替林 75mg ,po ,bid。 2组均联合奋乃静 8mg ,po ,bid。 6wk为一个疗程。结果 :对抑郁症状的治疗 ,氟西汀组显效率为 76 % ,阿米替林组为 75 % ;对精神病性症状 ,2组显效率分别为 80 % ,82 %。 2组疗效经Ridit分析P >0 .0 5。而在HAMD“焦虑 /躯体化”因子分下降方面 ,氟西汀组更为显著。氟西汀组常见不良反应为口干(2 8% ) ,便秘 (2 1% ) ,视力模糊 (14 % ) ,恶心呕吐(10 % ) ,兴奋或激越 (10 % )等。结论 :氟西汀联合奋乃静治疗PD疗效肯定 ,不良反应较少 ,具有更高的依从性。

Fluoxetine combined with perphenazine in treatment of psychotic depression

AIM: To study the efficacy and safety of fluoxetine combined with perphenazine in the treatment of psychotic depression. METHODS: Fluoxetine combined with perphenazien group(fluoxetive group) of twenty nine patients was treated with fluoxetine 20 mg, po ,qd. Amitriptyline combined with perphenazine group(amitriptyline group) of twenty eight patient was treated with amitriptyline 75 mg, po ,bid. Both groups were treated with perphenazine 8 mg, po, bid for 6 wk. RESULTS: In the treatment of depressin symptoms, the significant improvement rate of fluoxetine group was 76 %, that of amitriptyline group was 75 %. In the treatment of psychiatric symptom, the significant improvement rate of both groups was 82 % in amitriptyline group and 80 % in fluoxetine group, respectively (Ridit analysis, P >0.05). However, fluoxetine group was more prominent in the reducing of anxiety/somatization factor of HAMD. Usual adrerse reactions were dry mouth (28 %), constipation (21 %), blurred vision (14 %), nausea, and emesis (10 %), excitation or agitation (10 %), akathisia (7 %) and so on in fluoxetine group. CONCLUSION: Combination of fluoxetine with perphenazine is effective in treating psychotic depression,and it has less adverse reactions and well compliance.