实验动物屏障环境常用消毒药品皮肤刺激实验

目的观察2％含量的过氧乙酸、0．2％含量的过氧乙酸、0．2％含量的次氯酸钠和2％含量的戊二醛溶液，对实验动物和工作人员皮肤是否有刺激性。方法2％含量的过氧乙酸、0．2％含量的过氧乙酸、0．2％含量的次氯酸钠和2％含量的戊二醛溶液短期接触豚鼠皮肤（斑贴）后，在规定的时间内，通过采用评分的方法来判定对豚鼠皮肤所产生的刺激反应。结果2％含量的戊二醛溶液对皮肤有轻微刺激，有水肿现象发生，1h后症状消失，并有棕黄色着色性，其他几种消毒药品均对豚鼠皮肤无刺激性反应。结论2％含量的戊二醛溶液对实验动物和工作人员皮肤有轻微刺激，并有棕黄色着色性。

Skin Irritation Caused by Commonly Used Disinfectants in Laboratory Animal Barrier Environment

Objective To investigate whether commonly used disinfectants cause skin irritation reactions in laboratory animals and personnel. Methods The following disinfectants were used in this experiment: 2% peracetic acid, 0.2% peracetic acid, 0.2% sodium hypochlorite and 2% glutaraldeldehyde. After short-term contact with the skin of guinea pigs (spot), the irritation reactions were evaluated. Results 2% glutaraldeldehyde solution caused slight skin erythema and edema, vanished after 1 hour, and a yellowish brown coloration was left. Other several kind of disinfectants did not lead to apparent skin irritation reactions in the guinea pigs. Conclusions 2% glutaraldehhyde solution may cause slight skin irritation reaction and yellowish brown coloration in both experimental animal and may be harmful to personnel.