Mapping quantitative traits with random and with ascertained sibships |
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Authors: | Peng Jie Siegmund D |
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Institution: | Department of Statistics, Stanford University, Stanford, CA 94305, USA. |
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Abstract: | Use of a robust score statistic based on a variance components model to map quantitative trait loci in randomly sampled pedigrees is reviewed. Sibships ascertained through a single proband are discussed. Under a standard assumption of multivariate normality, two suggested methods of ascertainment correction are shown to be asymptotically equivalent when the number of sibships is large. |
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