Antitumor activity of specific immunotherapy with mucin containing CA 125 antigen in mice with CaO 1 ovarian carcinoma |
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| Authors: | B. S. Amandzholov S. M. Sitdikova Yu. S. Lebedin S. V. Chukanov A. Yu. Toptygin L. V. Manzyuk F. V. Donenko |
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| Affiliation: | (1) N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, USSR;(2) Hema-Medika Research-and-Production Company, Moscow |
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| Abstract: | Experiments in CBA mice with transplanted CaO 1 ovarian carcinoma possessing common antigenic determinants with human ovarian carcinoma showed that specific immunotherapy with mucin containing CA 125 antigen inhibited tumor growth by 60% and prolonged antimal lifespan by 40–60% in comparison with the control. The correlation coefficient between the tumor size and antibody titer after injection of mucin was −0.4 for IgM and −0.6 for IgG. Titration of IgG may be used for monitoring of the efficiency of specific immunotherapy. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 4, pp. 456–458, April, 2000 |
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| Keywords: | CA 125 antigen specific immunotherapy CaO 1 murine ovarian carcinoma |
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