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二甲双胍降糖外作用的研究进展
引用本文:杨迪[综述] 叶山东[审校]. 二甲双胍降糖外作用的研究进展[J]. 国际病理科学与临床杂志, 2013, 0(6): 553-557
作者姓名:杨迪[综述] 叶山东[审校]
作者单位:安徽医科大学附属省立医院内分泌科,合肥230001
摘    要:二甲双胍是一安全有效的抗糖尿病药物,已被广泛推荐为治疗2型糖尿病的一线用药。随着对二甲双胍研究的深入,发现其作用不仅局限于降低糖尿病患者血糖,且对多囊卵巢综合征和非酒精性脂肪肝病等也有一定益处。此外,二甲双胍可通过激活腺苷酸活化蛋白激酶,抑制哺乳动物雷帕霉素靶蛋白通路等阻滞癌症细胞生长。近年来,其抗动脉粥样硬化、改善血管内皮功能等对心血管的保护作用也成为研究的热点。

关 键 词:二甲双胍  肿瘤  心血管疾病  妊娠糖尿病  脂肪肝  多囊卵巢综合征

Advances in the study on metformin beyond its hypoglycemic effect
Affiliation:YANG Di, YEShandong (Department of Endocrinology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China)
Abstract:As a safe and effective antidiabetic drug, metformin has been considered to be the first line drug for the therapy of diabetes. With further research on metformin, it turns out that metformin can not only lower blood glucose but also display certain benefits for patients with polycystic ovary syndrome and nonalcoholic fatty liver disease, which is independent of the hypoglycemic effect of metformin. Furthermore, metformin can block cancer cells growth by activation of AMP-activated protein kinase and inhibition of mammalian target of rapamycin signaling pathway. In recent years, the effects of metformin on anti-atherosclerosis, endothelial function protection and other cardiovascular benefits have also become a research hotspot.
Keywords:metformin  tumor  cardiovascular disease  gestational diabetes mellitus  fattyliver  polycystic ovary syndrome
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