预混胰岛素对新诊断2型糖尿病患者血糖控制疗效观察

目的：评估预混胰岛素（优泌乐50、优泌林70/30和诺和锐30）对新诊断2型糖尿病的临床疗效。方法：新诊断的2型糖尿病患者（143例）随机分为优泌乐50组（48例）、优泌林70/30组（47例）和诺和锐30组（48例）,于每日早、晚餐前皮下注射,12周后,观察并比较3组空腹血糖（FPG）、餐后2 h血糖（2 hPG）、糖化血红蛋白C（HbA1c）的变化。结果：3组FPG水平相似;优泌乐50组2 hPG优于其它2组,且HbA1c水平更低（P〈0.05）。结论：优泌乐50、优泌林70/30及诺和锐30对新诊断2型糖尿病PG控制疗效肯定,优泌乐50对2 hPG的控制优于优泌林70/30和诺和锐30。

Efficacy of Premixed Insulins in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

Objective： To evaluate the efficacy of premixed insulins （lispro mix 50/50, humulin 70/30 and aspart 30） in patients with newly diagnosed type 2 diabetes mellitus. Methods： A total of 143 newly diagnosed type 2 diabetes mellitus were randomly divided into lispro mix 50/50 （48 cases）, humulin 70/30 （47 cases）and aspart 30 （48 cases）groups. After treatment for 12 weeks, the fasting plasma glucose（FPG）, postprandial plasma glucose（2 hPG）, glycosylated hemoglobin （HbA1 c）were observed and compared. Results： The FPG was similar in three groups. The 2 hPG and HbA1 c were significantly more effective in the lispro mix 50/50 group than those in other groups （P〈0.05）. Conclusion： Lispro mix 50/50, humulin 70/30 and aspart 30 are effective in treatment of newly diagnosed type 2 diabetes mellitus. Lispro mix 50/50 is more effective in controlling postprandial plasma glucose.